| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-smol:TTA:out-urn:agi-llid:5465::positive |
| Entities | TTA --+> PPARA |
| References | 4 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i33 p30525 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/33/30525 |
| MedLine Reference | 12756242:1032 |
| Sentence | TTA has been demonstrated to function as a ligand and activator of the PPAR subtypes PPARalpha, PPARdelta, and PPARgamma ( 4 , 7 A?A?A? 9 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| CellType | hepatocyte |
| Journal Reference | v40 i11 p2099 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/11/2099 |
| MedLine Reference | 10553013:1025 |
| Sentence | TTA also enhanced the transcriptional activity of chimeras containing the DNA binding domain of the yeast transcription factor Gal4 fused to the ligand binding domain of either human PPAR or human PPAR . |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v41 i4 p538 (2000) |
| Journal Link | http://www.jlr.org/cgi/content/full/41/4/538 |
| Organ | liver |
| MedLine Reference | 10744774:1199 |
| Sentence | Numerous compounds including natural fatty acids and TTA have been shown to bind to and activate PPAR . |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i5 p742 (2002) |
| Tissue | fat |
| Journal Link | http://www.jlr.org/cgi/content/full/43/5/742 |
| MedLine Reference | 11971945:1054 |
| Sentence | We show that TTA efficiently activates peroxisome proliferator-activated receptor (PPAR) and PPAR , whereas activation of PPAR requires relatively high concentrations of TTA. |