| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:121250-47-3:out-urn:agi-llid:5465::positive |
| Entities | CLA --+> PPARA |
| References | 14 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v40 i8 p1426 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/8/1426 |
| MedLine Reference | 10428978:1032 |
| Sentence | Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPAR . |
| Organism | Mus musculus |
|---|---|
| CellLineName | 3T3 L1 |
| Journal | Lipid Res |
| Journal Reference | v44 i8 p1441 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/8/1441 |
| MedLine Reference | 12754280:1216 |
| Sentence | Along these lines, earlier studies have shown a down-regulation of PPAR and aP2 mRNA expression after stimulation of 3T3-L1 cells with a mixture of CLA until D7 of differentiation ( 48 , 49 ). |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | 3T3 L1 |
| Journal | Nutrition |
| CellType | adipocyte |
| Journal Reference | v130 i8 p1920 (2000) |
| Journal Link | http://www.nutrition.org/cgi/content/full/130/8/1920 |
| MedLine Reference | 10917902:1130 |
| Sentence | The expression of the SCD2, aP2, PPAR 2 and FAS mRNAs was reduced only slightly by trans -10, cis -12 CLA. |
| Journal | Nutrition |
|---|---|
| CellType | t cell |
| Journal Reference | v133 i10 p3204 (2003) |
| Journal Link | http://www.nutrition.org/cgi/content/full/133/10/3204 |
| MedLine Reference | 14519812:1302 |
| Sentence | In examining the mechanism of T-cell immunoregulation, dietary CLA differentially modulated PPAR-alpha and PPAR-gamma expression in PCV2-infected pigs. |
| Organism | Mus musculus |
|---|---|
| Journal | Nutrition |
| Journal Reference | v129 i3 p602 (1999) |
| Tissue | fat |
| Journal Link | http://www.nutrition.org/cgi/content/full/129/3/602 |
| MedLine Reference | 10082762:1139 |
| Sentence | Using a transfection study, they demonstrated that CLA and troglitazone can activate PPAR transcription. |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Nutrition |
| Journal Reference | v129 i12 p2135 (1999) |
| Tissue | epithelia |
| Journal Link | http://www.nutrition.org/cgi/content/full/129/12/2135 |
| MedLine Reference | 10573540:1209 |
| Sentence | In agreement with its high binding affinity, c 9, t 11-CLA was also the most efficacious PPAR activator, as determined in a PPAR -reporter gene assay system. |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i2 p290 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/2/290 |
| MedLine Reference | 11861671:1342 |
| Sentence | Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPAR . |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i12 p2112 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/12/2112 |
| MedLine Reference | 12454273:1469 |
| Sentence | Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPARalpha. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | adipocyte |
| Journal Reference | v44 i7 p1287 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/7/1287 |
| MedLine Reference | 12730300:1044 |
| Sentence | Since trans -10, cis -12 CLA is only a weak activator of PPAR and has been shown to interfere with lipid accumulation in adipocytes in vivo and in vitro, we hypothesized that this CLA isomer might be a partial agonist of PPAR , or alternatively may interfere with endogenous agonist production. |
| Journal | Nutrition |
|---|---|
| Journal Reference | v131 i4 p1129 (2001) |
| Journal Link | http://www.nutrition.org/cgi/content/full/131/4/1129 |
| MedLine Reference | 11285313:1275 |
| Sentence | Conjugated linoleic acid is a potent naturally occurring ligand and activator of PPAR . |
| Journal | Nutrition |
|---|---|
| Journal Reference | v131 i11 p3133S (2001) |
| Tissue | mammary |
| Journal Link | http://www.nutrition.org/cgi/content/full/131/11/3133S |
| MedLine Reference | 11694659:1508 |
| Journal | Nutrition |
|---|---|
| Journal Reference | v132 i11 p3540S (2002) |
| Journal Link | http://www.nutrition.org/cgi/content/full/132/11/3540S |
| MedLine Reference | 12421885:1013 |
| Journal | Nutrition |
|---|---|
| Journal Reference | v134 i1 p68 (2004) |
| Tissue | fat |
| Journal Link | http://www.nutrition.org/cgi/content/full/134/1/68 |
| MedLine Reference | 14704295:1133 |
| Organism | Rattus norvegicus |
|---|---|
| Organ | liver |
| MedLine Reference | 9535724:1 |