| Entities | PPARA ---- LPL |
|---|---|
| References | 32 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:inout-urn:agi-llid:4023::unknown |
| CellType | macrophage |
|---|---|
| Journal | ATVB |
| Journal Reference | v20 i1 p104 (2000) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/20/1/104 |
| MedLine Reference | 10634806:1149 |
| Sentence | This view is supported by the observation that PPAR agonists increase LPL gene expression 14 15 50 51 and by the demonstration of a PPRE site in the regulatory sequence of the human LPL gene. 14 The parallel induction of PPAR and LPL gene expression in glucose-treated macrophages is consistent with the view that the transcriptional effect of glucose on macrophage LPL that we previously reported 28 may involve this PPAR isoform. |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Organ | liver |
| Journal | Mol. Endocrin |
| Journal Reference | v17 i12 p2477 (2003) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/12/2477 |
| MedLine Reference | 14525954:1341 |
| Sentence | This is reminiscent of the differential cell specific regulation of the LPL promoter by PPARalpha and -gamma agonists in adipose and liver. |
| Organism | Mus musculus |
| Journal | PNAS |
|---|---|
| Journal Reference | v100 i5 p2730 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/5/2730 |
| MedLine Reference | 12606719:1183 |
| Sentence | The latter may include a possible positive feedback loop through PPARalpha leading to increased LPL expression and activity by inducing LPL and repressing ApoCIII. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Organ | liver |
| Journal | Endocrin. Metabol |
| Journal Reference | v286 i2 pE168 (2004) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/286/2/E168 |
| MedLine Reference | 14519597:1025 |
| Sentence | Expression of lipoprotein lipase (LPL) is regulated by PPARalpha in the liver ( 26 , 32 ) and PPARgamma in adipocytes ( 32 ). |
| Tissue | muscle |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v145 i7 p3158 (2004) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/7/3158 |
| MedLine Reference | 15059948:1207 |
| Sentence | Both PPARalpha and PPARgamma agonists modulate the expression of LPL at the level of mRNA ( 43 ), and it is likely therefore that tesaglitazar alters TG-derived fatty acid metabolism. |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i7 p1035 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/7/1035 |
| MedLine Reference | 12091487:1270 |
| Sentence | We propose that reduced PE methylation contributes to the prominent TG lowering effect of bezafibrate, in addition to the PPAR -mediated transcriptional regulation of apoC-III and lipoprotein lipase that is common to all fibrates. |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v14 i2 p307 (2000) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/14/2/307 |
| MedLine Reference | 10674402:1025 |
| Sentence | In adipocytes, PPAR is responsible for the expression of adipose differentiation-related genes such as 422/aP2, phosphoenol pyruvate carboxykinase, and lipoprotein lipase. |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Organ | liver |
| Journal | Heart Circul |
| Journal Reference | v281 i2 pH888 (2001) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/281/2/H888 |
| MedLine Reference | 11454595:1024 |
| Sentence | Selective PPAR-alpha and PPAR-gamma ligands increase LPL expression in liver and adipose tissue, respectively ( 2 , 16 , 21 , 24 , 29 , 31 ). |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| MedLine Reference | 10774955:6 |
| Sentence | Upon fibrate activation, PPARalpha down-regulates hepatic apolipoprotein C-III and increases lipoprotein lipase gene expression, key players in triglyceride metabolism. |
| CellType | adipocyte |
|---|---|
| Tissue | fat |
| Organ | liver |
| Journal | ATVB |
| Journal Reference | v22 i5 p717 (2002) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/22/5/717 |
| MedLine Reference | 12006382:1074 |
| Sentence | In obese animal models, TZDs and non-TZD glitazones decrease the circulating levels of triglycerides by inducing lipolysis (via activation of LPL expression in adipocytes) and clearance of triglyceride-rich lipoproteins. 52 A?A?A? 54 In rodents, simultaneous administration of PPAR and PPAR activators results in a more efficient hypotriglyceridemic activity, which is likely due to combined actions on liver apoC-III and adipose tissue LPL expression. 55 The induction of LPL by PPAR promotes FA delivery, whereas induction of FATP and ACS results in enhanced FA uptake. |
| Tissue | fat |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i3 p455 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/3/455 |
| MedLine Reference | 12562865:1221 |
| Tissue | skeletal muscle |
|---|---|
| Organ | heart |
| MedLine Reference | 10431661:5 |
| Tissue | vascular |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v18 i6 p1321 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/6/1321 |
| MedLine Reference | 15087471:1123 |
| Journal | PNAS |
|---|---|
| Journal Reference | v98 i5 p2323 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/5/2323 |
| MedLine Reference | 11226238:1172 |
| Organism | Mus musculus |
| Journal | Endocrinology |
|---|---|
| Journal Reference | v144 i6 p2201 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/6/2201 |
| MedLine Reference | 12746275:1054 |
| CellType | macrophage |
|---|---|
| MedLine Reference | 11852057:4 |
| Journal | JPET |
|---|---|
| Journal Reference | v309 i3 p861 (2004) |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/309/3/861 |
| MedLine Reference | 14960661:1234 |
| Organism | Mus musculus |
| Journal | Diabetes |
|---|---|
| Journal Reference | v50 i3 p660 (2001) |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/50/3/660 |
| MedLine Reference | 11246888:1179 |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | Diabetes |
| Journal Reference | v52 i2 p291 (2003) |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/52/2/291 |
| MedLine Reference | 12540599:1187 |
| Organism | Rattus norvegicus |
| Tissue | fat |
|---|---|
| Organ | liver |
| Journal | Endocrinology |
| Journal Reference | v145 i4 p1640 (2004) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/4/1640 |
| MedLine Reference | 14701675:1269 |
| Organism | Mus musculus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v40 i3 p565 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/3/565 |
| MedLine Reference | 10064745:1612 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v40 i8 p1426 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/8/1426 |
| MedLine Reference | 10428978:1206 |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Organ | liver |
| Journal | Lipid Res |
| Journal Reference | v40 i11 p2099 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/11/2099 |
| MedLine Reference | 10553013:1072 |
| Organism | Mus musculus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v42 i5 p716 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/5/716 |
| MedLine Reference | 11352978:1491 |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v42 i10 p1543 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/10/1543 |
| MedLine Reference | 11590209:1269 |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i1 p74 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/1/74 |
| MedLine Reference | 11792725:1220 |
| Organism | Rattus norvegicus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i5 p742 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/5/742 |
| MedLine Reference | 11971945:1768 |
| Organism | Rattus norvegicus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i6 p936 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/6/936 |
| MedLine Reference | 12032169:1729 |
| Organism | Mus musculus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i9 p1400 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/9/1400 |
| MedLine Reference | 12235171:1387 |
| Organism | Mus musculus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v39 i1 p17 (1998) |
| Journal Link | http://www.jlr.org/cgi/content/full/39/1/17 |
| MedLine Reference | 9469582:1532 |
| Organism | Rattus norvegicus |
| Tissue | epithelia |
|---|---|
| Organ | colon |
| Journal | Mol. Endocrin |
| Journal Reference | v16 i9 p2065 (2002) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/16/9/2065 |
| MedLine Reference | 12198243:1378 |
| MedLine Reference | 11712864:2 |
|---|