| Entities | ACOX1 ---- PPARA |
|---|---|
| References | 27 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:inout-urn:agi-llid:51::positive |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v270 i22 p13470 (1995) |
| Journal Link | http://www.jbc.org/cgi/content/full/270/22/13470 |
| MedLine Reference | 7768950:1117 |
| Sentence | It is noteworthy that the C3P sequence of the apoC-III gene is homologous to the peroxisomal acyl-CoA oxidase promoter sequence which binds PPAR in the course of inducing transcriptional activation of peroxisomal genes by HD/PP ( 23 , 24 , 25 ) . |
| Organism | Rattus norvegicus |
| MedLine Reference | 7741763:1 |
|---|---|
| Sentence | Binding of PPAR to the acyl-CoA oxidase promoter requires heterodimerization with the retinoid X receptor (RXR), and subsequent transactivation is strongest when ligands for both PPAR and RXR are present. |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Endocrin. Metabol |
| Journal Reference | v281 i6 pE1197 (2001) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/281/6/E1197 |
| MedLine Reference | 11701434:1045 |
| Sentence | In the liver, PPARalpha has been shown to increase the expression of acyl-CoA oxidase in response to binding of various fatty acids ( 22 ). |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i33 p23577 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/33/23577 |
| MedLine Reference | 10438539:1138 |
| Sentence | On the other hand, WY 14,643 induced the transcription of acyl-CoA oxidase severalfold. which is consistent with prior findings that ligand activation of PPARalpha induces peroxisomal acyl-CoA oxidase promoter activity ( 18 ). |
| CellType | hepatocyte |
|---|---|
| Organ | liver |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i36 p28285 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/36/28285 |
| MedLine Reference | 10866995:1075 |
| Sentence | In mice fed the control diet, PPARalpha deficiency caused a reduction in the level of acyl-CoA oxidase (AOX ) and cytochrome P450 4A1 (CYP4A1 ) mRNA encoding the key enzymes involved in fatty acid eta- and omega-oxidation pathways (Fig. 1 ). |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i30 p27950 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/30/27950 |
| MedLine Reference | 11371553:1301 |
| Sentence | However, transient transfection of primary cultures of guinea pig hepatocytes with expression vectors for either mouse, guinea pig, or human PPARalpha conferred increases in the expression of rat acyl-CoA oxidase gene reporter constructs and also in the enzymatic activity of endogenous acyl-CoA oxidase in response to peroxisome proliferators ( 56 ). |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i34 p31521 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/34/31521 |
| MedLine Reference | 11418601:1206 |
| Sentence | It could be possible that PPARalpha modulated the expression of another transcription factor that interacts with the acyl-CoA oxidase promoter and modified basal peroxisomal eta-oxidation activity. |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i45 p42485 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/45/42485 |
| MedLine Reference | 11551940:1166 |
| Sentence | Both human and mouse PPARalpha caused marked increases in the protein content of AOX as well as L-PBE , the first two enzymes of the inducible peroxisomal eta-oxidation system in PPARalpha -/- mouse liver in response to structurally different PPARalpha ligands. |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v271 i4 p2147 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/4/2147 |
| MedLine Reference | 8567672:1040 |
| Sentence | The discovery of PPAR isoforms has facilitated the identification of PPRE in the upstream regions of the rat ACOX gene ( 17 , 24 ) . |
| Organism | Rattus norvegicus |
| CellType | hepatocyte |
|---|---|
| Journal | JPET |
| Journal Reference | v299 i2 p691 (2001) |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/299/2/691 |
| MedLine Reference | 11602682:1036 |
| Sentence | Devchand et al. (1996) demonstrated that treatment of isolated rat hepatocytes with LTB 4 or the PPARalpha agonist WY-14,643 rapidly increased mRNA levels of acyl-CoA oxidase, an enzyme of the peroxisomal eta-oxidation pathway of fatty acids, presumably through activation of PPARalpha. |
| Organism | Rattus norvegicus |
| CellLineName | MORRIS |
|---|---|
| MedLine Reference | 7548195:8 |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| MedLine Reference | 10725470:10 |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| MedLine Reference | 11701232:2 |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| MedLine Reference | 12213584:6 |
| Journal | Nutrition |
|---|---|
| Journal Reference | v133 i1 p57 (2003) |
| Journal Link | http://www.nutrition.org/cgi/content/full/133/1/57 |
| MedLine Reference | 12514267:1221 |
| Organism | Rattus norvegicus |
| CellType | hepatocyte |
|---|---|
| Journal | Carcinogenesis |
| Journal Reference | v20 i3 p369 (1999) |
| Journal Link | http://carcin.oupjournals.org/cgi/content/full/20/3/369 |
| MedLine Reference | 10190548:1011 |
| Organism | Rattus norvegicus |
| Journal | Gastr. Liver Phys |
|---|---|
| Journal Reference | v284 i2 pG302 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/2/G302 |
| MedLine Reference | 12388208:1018 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i27 p19228 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/27/19228 |
| MedLine Reference | 10383430:1216 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i47 p47232 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/47/47232 |
| MedLine Reference | 14500732:1114 |
| Organism | Mus musculus |
| MedLine Reference | 15209628:14 |
|---|---|
| Organism | Rattus norvegicus |
| Journal | Mol. Pharm |
|---|---|
| Journal Reference | v64 i2 p355 (2003) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/64/2/355 |
| MedLine Reference | 12869640:1026 |
| Journal | Eur. J. Biochem |
|---|---|
| Journal Reference | v267 i13 p4063 (2000) |
| Journal Link | http://www.ejbiochem.org/cgi/content/full/267/13/4063 |
| MedLine Reference | 10866807:1149 |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i22 p15775 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/22/15775 |
| MedLine Reference | 10336479:1142 |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| MedLine Reference | 9361824:9 |
| Tissue | fat |
|---|---|
| MedLine Reference | 11007938:17 |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| MedLine Reference | 15475571:6 |
| Organism | Mus musculus |
| CellLineName | db |
|---|---|
| Organ | kidney |
| Journal | Renal Phys |
| Journal Reference | v286 i5 pF913 (2004) |
| Journal Link | http://ajprenal.physiology.org/cgi/content/full/286/5/F913 |
| MedLine Reference | 15075187:1222 |
| Organism | Mus musculus |