| Entities | CYP7A1 ---- PPARA |
|---|---|
| References | 12 |
| Connectivity | 2 |
| Effect | negative |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5465:inout-urn:agi-llid:1581::negative |
| CellLineName | HepG 2 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i15 p10918 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/15/10918 |
| MedLine Reference | 10753890:1220 |
| Sentence | We observed that peroxisome proliferator-activated receptor alpha/RXRalpha inhibited CYP7A1 reporter activity in HepG2 cells by interfering with HNF4 binding to the gene ( 30 ). |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i50 p47154 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/50/47154 |
| MedLine Reference | 11606578:1046 |
| Sentence | Recent studies indicate that PPARalpha may exert regulatory control over CYP7A1 ( 29-31 ) and CYP8B1 ( 32 ), thereby potentially extending the physiological roles of this receptor. |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v275 i17 p12530 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/17/12530 |
| MedLine Reference | 10777541:1075 |
| Sentence | Human CYP7A1 and murine Cyp7a1 gene promoters are stimulated by PPARalpha/RXRalpha activators. |
| Organism | Mus musculus |
| CellLineName | HepG 2 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i35 p32852 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/35/32852 |
| MedLine Reference | 12810707:1045 |
| Sentence | In human hepatoma HepG2 cells, the PPARalpha ligand Wy 14643 suppresses CYP7A1 gene promoter activity ( 28 ). |
| Organism | Mus musculus |
| CellLineName | HepG 2 |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v41 i3 p514 (2000) |
| Journal Link | http://www.jlr.org/cgi/content/full/41/3/514 |
| MedLine Reference | 10744771:1163 |
| Sentence | HNF-4 protein expression level is reduced by Wy14,643 treatment in HepG2 cells To further investigate the mechanism by which PPAR represses CYP7A1 transcription, we studied the effect of Wy14,643 and PPAR on the expression of HNF-4 in HepG2 cells. |
| Organism | Rattus norvegicus |
| Tissue | fecal |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2049 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2049 |
| MedLine Reference | 12897186:1189 |
| Sentence | It is known that PPARalpha reduces CYP7A1 transcription in vitro ( 47 ) and that cipofibrate decreases bile acid synthesis in rats, leading to a decline in fecal bile acid output ( 48 ). |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 11042130:8 |
| Sentence | It is concluded that, whereas PPAR alpha can affect CYP7A1 gene transcription in vitro through an indirect action, probably by competing for co-factors, this is unlikely to be a major influence on Cyp7a1 activity under normal physiological conditions. |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| MedLine Reference | 12117567:1 |
| Sentence | Peroxisome proliferator-activated receptor alpha (PPARalpha; NR1C1) and liver X receptor alpha (LXRalpha; NR1H3) are two nuclear receptors that stimulate the murine Cyp7a1 gene. |
| Organism | Mus musculus |
| MedLine Reference | 14960721:1 |
|---|---|
| Sentence | In this study, we determined if LXRalpha:PPARalpha can also regulate human CYP7A1 gene promoter activity. |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v284 i4 pG551 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/4/G551 |
| MedLine Reference | 12631556:1141 |
| Sentence | In the liver, PPARalpha appears to stimulate CYP8B1 and to decrease CYP7A1 expression ( 14 ). |
| CellType | hepatocyte |
|---|---|
| Organ | liver |
| Journal | Lipid Res |
| Journal Reference | v45 i6 p1051 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/6/1051 |
| MedLine Reference | 15026425:1052 |
| Organism | Mus musculus |
| CellType | hepatocyte |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v281 i2 pG393 (2001) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/281/2/G393 |
| MedLine Reference | 11447020:1307 |
| Organism | Rattus norvegicus |