| References | 5 |
|---|---|
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| Modification Type | phosphorylation |
| URN | urn:agi-ProtModification:inout-urn:agi-llid:1432:out-urn:agi-llid:5465::positive |
| Entities | PPARA <+-- MAPK14 |
| MedLine Reference | 11577087:1090 |
|---|---|
| Sentence | Labeled PPARalpha was detected via Western blotting with anti-PPARalpha antisera. p38 MAPK Directly Phosphorylates PPARalpha-- The phosphorylation of PPARalpha shown above could occur as a result either of direct phosphorylation by SAPKs or phosphorylation via other downstream kinases. |
| Source | Curated |
| Organ | heart |
| Organism | Rattus norvegicus |
| CellType | myocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i48 p44495 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/48/44495 |
| MedLine Reference | 12032169:1398 |
|---|---|
| Sentence | Kelly. 2001. p38 mitogen-activated protein kinase activates peroxisome proliferator-activated receptor alpha: a potential role in the cardiac metabolic stress response. |
| Organ | heart |
| Organism | Mus musculus |
| Journal | Lipid Res |
| Journal Reference | v43 i6 p936 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/6/936 |
| MedLine Reference | 12414803:1219 |
|---|---|
| Sentence | In any case, both studies show that p38MAPK activity regulates PPAR/RXR action on UCP-1 gene transcription. |
| Organism | Rattus norvegicus |
| CellLineName | PAZ6 |
| CellType | adipocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i1 p263 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/1/263 |
| MedLine Reference | 12502492:1197 |
|---|---|
| Sentence | Inhibition of p38 MAPK may thus inhibit C/EBP and PPAR- activation and block adipocyte differentiation ( 32 ) in this way. |
| CellType | adipocyte |
| Journal | Diabetes |
| Journal Reference | v52 i1 p43 (2003) |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/52/1/43 |
| MedLine Reference | 12816998:1150 |
|---|---|
| Sentence | Inhibition of the p38 MAP kinase represses activation-induced T-bet mRNA and protein expression The PPARalpha isoform, unlike PPARbeta, is unable to negatively regulate gene expression through a DNA-binding dependent mechanism ( 27 ). |
| Organism | Mus musculus |
| CellType | t cell |
| Journal | J. Immunol |
| Journal Reference | v171 i1 p196 (2003) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/171/1/196 |