| Name | Edf1 |
|---|---|
| Description | endothelial differentiation-related factor 1 |
| Owner | Public |
| URN | urn:agi-llid:8721 |
| Connectivity | 7 |
| Notes | This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene. Multiprotein bridging factor-1 (MBF-1) is a cofactor for nuclear receptors that regulate lipid metabolism. |
| Microarray ID | 1375189_at |
|---|---|
| rc_aa891746_at | |
| 1438503_x_at | |
| 1440151_s_at | |
| 1440152_x_at | |
| 1448266_at | |
| 96322_at | |
| A_51_P160564 | |
| A_51_P160567 | |
| 209058_at | |
| 209059_s_at | |
| RC_AA598725_at | |
| A_23_P60376 | |
| A_14_P130205 | |
| A_32_P776017 | |
| OH3856 |
| Chromosome position | 9q34.3 |
|---|---|
| 3p13 | |
| 2 A3 |
| GO ID | 0005622 |
|---|---|
| 0016563 | |
| 0003677 | |
| 0005516 | |
| 0005634 | |
| 0006350 | |
| 0006355 | |
| 0030154 | |
| 0007275 |
| Alias | 0610008L11Rik |
|---|---|
| Edf1 | |
| endothelial differentiation-related factor 1 | |
| hypothetical protein 1-9 | |
| MBF1 | |
| MGC9058 | |
| multiprotein bridging factor 1 | |
| multiprotein bridging factor I | |
| Edf I | |
| hypothetical protein 1 IX | |
| MBF I | |
| endothelial differentiation-related factor I | |
| CAP-19 | |
| calmodulin-associated peptide-19 | |
| LOC304464 | |
| AA409425 |
| Organism | Rattus norvegicus |
|---|---|
| Homo sapiens | |
| Mus musculus |
| MedLine Reference | 12466851 |
|---|
| LocusLink ID | 66041 |
|---|---|
| 296570 | |
| 80387 | |
| 8721 | |
| 103556 | |
| 59022 |
| FunctionalClass | transcriptional activator |
|---|---|
| DNA binding | |
| calmodulin binding |
| GO Cellular Component | intracellular |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | PPAR all |
|---|---|
| PPARalpha | |
| LXR | |
| LRH-1 |
| GO Biological Process | cell differentiation |
|---|---|
| regulation of transcription, DNA-dependent | |
| transcription | |
| development |
| Group | Transcription factors |
|---|
| Source | Curated |
|---|