| Owner | Public |
|---|---|
| URN | urn:agi-DirectRegulation:inout-urn:agi-llid:5467:out-urn:agi-llid:9612::unknown |
| Entities | PPARD ---> NCOR2 |
| References | 3 |
| Effect | unknown |
| Connectivity | 2 |
| MedLine Reference | 11867749:1092 |
|---|---|
| Sentence | CV-1 cells were transfected with G4-SMRT and VP, VP-PPARdelta, or VP-PPARdelta LBD (VP-deltaLBD). ( D ) The ID1 of SMRT interacts with PPARdelta. |
| Journal | PNAS |
| Journal Reference | v99 i5 p2613 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/5/2613 |
| Organism | Mus musculus |
| MedLine Reference | 11069900:1269 |
|---|---|
| Sentence | PPARalpha and PPARgamma have been shown to interact with the SMRT ( 26 , 55 ) and the N-CoR corepressors ( 56 , 57 ), and we have shown that N-CoR and SMRT interact strongly with PPARdelta and repress transactivation by PPARdelta in a ligand-independent manner. 2 Whether cAMP-dependent enhancement of PPARdelta-mediated transactivation proceeds via protein kinase A-dependent phosphorylation of PPARdelta, dissociation of corepressor complexes, recruitment of coactivators, or by other mechanism(s) is currently under investigation. |
| Tissue | fat |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i5 p3175 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/5/3175 |
| Organism | Mus musculus |
| MedLine Reference | 2825137878 |
|---|---|
| Sentence | PPAR-delta interacts with SMRT. This interaction was modelled on a demonstrated interaction between PPAR-delta and SMRT from unspecified sources |