| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5467:out-urn:agi-llid:5468::unknown |
| Entities | PPARG <--- PPARD |
| References | 7 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i31 p21920 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/31/21920 |
| MedLine Reference | 10419513:1220 |
| Sentence | In conclusion, PPARdelta appears to be the primary target of LCFAs and controls PPARgamma gene expression. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i49 p38768 (2000) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/275/49/38768 |
| MedLine Reference | 10991946:1145 |
| Sentence | In contrast, expression of the dominant-negative PPARdelta resulted in a marked down-regulation of PPARgamma mRNA. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i5 p3175 (2001) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/276/5/3175 |
| MedLine Reference | 11069900:1037 |
| Sentence | Furthermore, fatty acid treatment of 3T3-C2 cells with forced expression of PPARdelta was demonstrated to promote both the expression of PPARgamma and adipose conversion, the latter in a manner depending on the combined treatment with fatty acids and a selective PPARgamma ligand ( 35 ). |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11867749:5 |
| Sentence | Similarly, stable expression of PPARdelta in 3T3-PPARgamma cells leads to inhibition of PPARgamma target gene expression and PPARgamma-mediated adipogenesis. |
| Journal | ATVB |
|---|---|
| CellType | macrophage |
| Journal Reference | v24 i2 p230 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/2/230 |
| MedLine Reference | 14592855:1082 |
| Sentence | Interestingly, some of the target genes for PPARgamma were also induced by PPARdelta ligands, suggesting that these two isoforms have overlapping transactivator functions in macrophages. 85 Macrophages contribute to lipoprotein metabolism by secreting apolipoproteins and enzymes involved in lipoprotein modification. |
| Journal | J. Biol. Chem |
|---|---|
| CellType | macrophage |
| Journal Reference | v276 i47 p44258 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/44258 |
| MedLine Reference | 11557774:1240 |
| Sentence | In the current study we have used highly selective agonists to demonstrate that both PPARdelta and PPARgamma differentially regulate the lipid accumulation in macrophages, with PPARdelta activation promoting lipid accumulation and PPARgamma promoting lipid clearance. |
| Journal | PNAS |
|---|---|
| Journal Reference | v100 i8 p4666 (1996) |
| Tissue | skeletal muscle |
| Journal Link | http://www.pnas.org/cgi/content/full/100/8/4666 |
| MedLine Reference | 12677001:1186 |
| Sentence | PPARD also negatively modulates PPARA and PPARG activity, both encoding proteins that positively regulate fatty acid metabolism in skeletal muscle ( 28 , 29 ). |