| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5467:out-urn:agi-llid:19::positive |
| Entities | ABCA1 <+-- PPARD |
| References | 7 |
| Connectivity | 2 |
| Effect | positive |
| Journal | ATVB |
|---|---|
| CellType | macrophage |
| Journal Reference | v24 i2 p230 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/2/230 |
| MedLine Reference | 14592855:1078 |
| Sentence | One study has demonstrated that PPARdelta can stimulate ABCA1 expression and cholesterol efflux in macrophages. 26 However, PPARdelta activation has also been shown to promote cholesterol accumulation in macrophages by upregulation of genes implicated in cholesterol uptake, including CD36 and SR-A, and downregulation of genes involved in lipid metabolism and efflux, such as cholesterol 27-hydroxylase (Cyp27) and apoE. 82 The basis for these reported differences is not clear. |
| Organism | Mus musculus |
|---|---|
| CellLineName | ec |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i28 p25448 (2003) |
| Tissue | endothelial |
| Journal Link | http://www.jbc.org/cgi/content/full/278/28/25448 |
| Organ | liver |
| MedLine Reference | 12704191:1105 |
| Sentence | It has been shown that PPARgamma activators are able to regulate LXR expression, and thereby indirectly influence ABCA1 mRNA levels ( 13 ), and that ligands for PPARdelta directly regulate the expression of ABCA1 via an unknown mechanism ( 14 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | macrophage |
| Journal Reference | v44 i11 p2049 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2049 |
| MedLine Reference | 12897186:1199 |
| Sentence | The recent report that a specific activator of PPARdelta was a potent stimulator of ABCA1 transcription in macrophages ( 54 ) indicates that ligands for PPARdelta could also play a role in regulating cholesterol absorption. |
| Organism | Mus musculus |
|---|---|
| Tissue | fecal |
| Organ | gastric |
| MedLine Reference | 15604518:5 |
| Sentence | Unexpectedly, PPARdelta activation led to enhanced fecal neutral sterol loss in both groups without any changes in intestinal Abca1, Abcg5, Abcg8, and 3-hydroxy-3-methylglutaryl-coenzyme A reductase expression. |
| Journal | PNAS |
|---|---|
| Journal Reference | v98 i9 p5306 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/9/5306 |
| Organ | gastric |
| MedLine Reference | 11309497:1054 |
| Sentence | In this report, we demonstrate that a selective PPARdelta agonist increases ABCA1 expression and cholesterol efflux from cells and increases HDLc in primates. |
| Organism | Mus musculus |
|---|---|
| Journal | PNAS |
| Journal Reference | v99 i1 p303 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/1/303 |
| Organ | intestine |
| MedLine Reference | 11756685:1194 |
| Sentence | In addition, PPARdelta can up-regulate ABCA1 expression and cholesterol efflux in multiple cell types ( 11 ), and the expression of liver fatty-acid binding protein in the gut ( 29 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v278 i12 p10119 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/12/10119 |
| Organ | liver |
| MedLine Reference | 12547832:1240 |
| Sentence | Liver X receptor ( 38-40 ), PPARalpha ( 41 ), PPARgamma ( 41 , 42 ), and PPARdelta ( 43 ) in complex with RXR have been documented to increase ABCA1 expression in macrophages but not hepatocytes. |