| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5467:out-urn:agi-llid:7352::positive |
| Entities | UCP3 <+-- PPARD |
| References | 3 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | L6 |
| Journal | Endocrinology |
| CellType | myotube |
| Journal Reference | v142 i10 p4189 (2001) |
| Tissue | skeletal muscle |
| Journal Link | http://endo.endojournals.org/cgi/content/full/142/10/4189 |
| MedLine Reference | 11564673:1012 |
| Sentence | Therefore, we conclude that UCP3 gene expression is increased by the activation of PPARdelta in L6 myotubes and postulate that PPARdelta mediates at least some part of the increased UCP3 gene expression by fatty acids in skeletal muscle in vivo . |
| Journal | Mol. Endocrin |
|---|---|
| Journal Reference | v17 i10 p1944 (2003) |
| Tissue | skeletal muscle |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/10/1944 |
| MedLine Reference | 12843208:1039 |
| Sentence | In cell cultures, PPARdelta activation has been claimed to be the main inducer of UCP3 mRNA expression, probably due to the lack of expression of PPARalpha in myogenic cells differentiated in culture ( 25 ). |
| Organism | Mus musculus |
|---|---|
| Tissue | fat |
| MedLine Reference | 14677574:4 |
| Sentence | PPAR(delta) also activates the heat-producing uncoupling enzymes in brown adipose tissue (UCP1 and 3) and muscle (UCP2). |