| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:67254-79-9:out-urn:agi-llid:5467::positive |
| Entities | fatty acid --+> PPARD |
| References | 7 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | osteoblast |
| Journal Reference | v274 i31 p21920 (1999) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/274/31/21920 |
| MedLine Reference | 10419513:1043 |
| Sentence | Finally, fatty acids promote adipose conversion of calvaria-derived osteoblasts or osteoma clonal cells that express PPARdelta but not PPARalpha and PPARgamma ( 22 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v270 i47 p28183 (1995) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/270/47/28183 |
| MedLine Reference | 7499310:1029 |
| Sentence | These effects of fatty acids are mediated by activation of a nuclear receptor called fatty acid-activated receptor (FAAR) expressed in a variety of tissues including adipose tissue and muscle( 17 ) . |
| Organism | Mus musculus |
|---|---|
| Journal | Eur. J. Biochem |
| CellType | adipocyte |
| Journal Reference | v259 i3 p801 (1999) |
| Journal Link | http://www.ejbiochem.org/cgi/content/full/259/3/801 |
| MedLine Reference | 10092867:1034 |
| Sentence | In particular, CCAAT enhancer-binding protein alpha (C/EBPalpha), peroxisome proliferator-activated receptor gamma2 (PPARgamma2), and fatty acid activated receptor (FAAR) are well characterized triggers for terminal differentiation [ 11 - 15 ]. |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v274 i12 p7913 (1999) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/274/12/7913 |
| MedLine Reference | 10075686:1030 |
| Sentence | The synthetic thiazolidinedione insulin sensitizers ( 11 ) and the prostaglandin derivative 15-deoxy-Delta 12,14 -prostaglandin J 2 bind and activate PPARgamma ( 12 , 13 ), while several polyunsaturated fatty acids and eicosanoids can serve to activate PPARdelta ( 7 , 9 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Lipid Res |
| CellType | hepatocyte |
| Journal Reference | v41 i9 p1390 (2000) |
| Journal Link | http://www.jlr.org/cgi/content/full/41/9/1390 |
| Organ | liver |
| MedLine Reference | 10974046:1040 |
| Sentence | The control of gene expression by fatty acids is currently thought to be mediated by ligand-dependent transcription factors including the peroxisome proliferator-activated receptor (PPAR) and the fatty acid-activated receptor (FAAR), members of the steroid hormone receptor superfamily ( 17 ) ( 18 ) ( 19 ) ( 20 ). |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 11007938:7 |
| Sentence | PPAR beta/delta, which is not very well known yet, appears to be more specifically activated by fatty acids. |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 11779158:2 |
| Sentence | PPARdelta is activated by unsaturated fatty acids, PGI2, and by synthetic ligands. |