| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:5467:out-urn:agi-cas:57-88-5::unknown |
| Entities | cholesterol <--- PPARD |
| References | 7 |
| Connectivity | 2 |
| Effect | unknown |
| MedLine Reference | 12746275:1123 |
|---|---|
| Sentence | In one study, PPARdelta activation potentiated cholesterol efflux through induction of the ABCA1 pathway, whereas the other demonstrated enhanced lipid accumulation using a different agonist ( 63 , 66 ). |
| Journal | Endocrinology |
| Journal Reference | v144 i6 p2201 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/6/2201 |
| MedLine Reference | 11557774:1212 |
|---|---|
| Sentence | PPARdelta Represses a Subset of Genes Involved in Cholesterol Efflux-- Upon activation of THP-1 cells we found that cholesterol 27-hydroxylase ( CYP27 ) and apolipoprotein E (apoE) were repressed by compound F (Fig. 7 , A and C ). |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i47 p44258 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/44258 |
| CellLineName | THP I |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12897186:1199 |
| CellType | macrophage |
| Sentence | The recent report that a specific activator of PPARdelta was a potent stimulator of ABCA1 transcription in macrophages ( 54 ) indicates that ligands for PPARdelta could also play a role in regulating cholesterol absorption. |
| Journal | Lipid Res |
| Journal Reference | v44 i11 p2049 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/11/2049 |
| MedLine Reference | 11309497:1034 |
|---|---|
| Sentence | Our results suggest that PPARdelta agonists may be effective drugs to increase reverse cholesterol transport and decrease cardiovascular disease associated with the metabolic syndrome X. |
| Journal | PNAS |
| Journal Reference | v98 i9 p5306 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/9/5306 |
| MedLine Reference | 11698662:1033 |
|---|---|
| Sentence | Recently, the function of PPARdelta in the regulation of reverse cholesterol transport and high-density lipoprotein metabolism was revealed through the use of a potent PPARdelta agonist, GW501516 ( 5 ). |
| Journal | PNAS |
| Journal Reference | v98 i24 p13919 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/24/13919 |
| Organism | Mus musculus |
|---|---|
| Organ | placenta |
| MedLine Reference | 11756685:1030 |
| CellType | trophoblast |
| Sentence | Recent studies with a synthetic agonist demonstrated that PPARdelta can induce reverse cholesterol transport and rectify lipoprotein profiles and triglyceride levels in obese Rhesus monkeys ( 11 ), placing it alongside the remaining PPARs in the regulation of lipid metabolism. |
| Journal | PNAS |
| Journal Reference | v99 i1 p303 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/1/303 |
| Tissue | egg |
|---|---|
| Organism | Mus musculus |
| Organ | skin |
| MedLine Reference | 11867749:1029 |
| Sentence | Recent studies have suggested that PPARdelta might play a role in cholesterol efflux ( 15 ), colon cancer ( 16 ), embryo implantation ( 17 ), preadipocyte proliferation ( 18 ), and epidermal maturation ( 19 ). |
| Journal | PNAS |
| Journal Reference | v99 i5 p2613 (2002) |
| Journal Link | http://www.pnas.org/cgi/content/full/99/5/2613 |