| Name | ANGPTL4 |
|---|---|
| Description | angiopoietin-like 4 |
| Owner | Public |
| URN | urn:agi-llid:51129 |
| Connectivity | 5 |
| Notes | Peroxisome proliferator-activated receptor gamma is a nuclear receptor which regulates adipose differentiation and glucose homeostasis. It acts through ligand-dependent transcriptional activation of target genes. This gene is one of the targets of peroxisome proliferator-activated receptor gamma and encodes an angiopoietin-like secreted glycoprotein. This gene also has been referred to as ANGPTL2, although a different gene exists with that same designation. Two transcript variants encoding the same protein have been found for this gene. Expression of peroxisome proliferator-activated receptors (PPARs) in human urinary bladder carcinoma and growth inhibition by its agonists. FIAF may partially exert its function via a truncated form. Peroxisome proliferator-activated receptor (PPARalpha and PPARgamma) agonists decrease lipoprotein lipase secretion and glycated LDL uptake by human macrophages. The results suggest that homocysteine may enhance vascular constrictive remodeling by inactivating PPAR-alpha and -gamma in ECs and PPAR-gamma in SMCs. This protein is a proangiogenic factor produced during ischemia and in conventional renal cell carcinoma. |
| Microarray ID | 221009_s_at |
|---|---|
| 223333_s_at | |
| rc_aa464188_s_at | |
| rc_c20975_at | |
| rc_t74893_at | |
| A_23_P159328 | |
| A_14_P123882 | |
| A_23_P159325 | |
| OH6103 | |
| 102114_f_at | |
| 1417130_s_at | |
| 95838_f_at | |
| 96119_s_at | |
| aa059883_s_at | |
| A_51_P338443 | |
| 48753_at |
| Chromosome position | 19p13.3 |
|---|---|
| 7q12 | |
| 17 B1 |
| GO ID | 0005554 |
|---|---|
| 0005615 | |
| 0051259 | |
| 0001525 | |
| 0001666 | |
| 0004857 | |
| 0005576 | |
| 0009267 | |
| 0030154 | |
| 0043066 | |
| 0045766 | |
| 0045834 | |
| 0051005 |
| Alias | PP-1158 |
|---|---|
| PP(1158) | |
| BK89 | |
| hepatic fibrinogen/angiopoietin-related protein | |
| ARP4 | |
| Farp | |
| fasting-induced adipose factor | |
| FIAF | |
| HFARP | |
| NG27 | |
| PGAR | |
| PPAR(gamma) angiopoietin related gene, angiopoietin-related protein | |
| PPAR(gamma) angiopoietin related protein | |
| PPARG angiopoietin related protein | |
| fibrinogen/angiopoietin-related protein | |
| hepatic angiopoietin-related protein | |
| ANGPTL4 | |
| angiopoietin-like IV | |
| major histocompatibility complex region NG27 | |
| Angiopoietin-related protein | |
| LOC362850 | |
| angiopoietin-like 4 | |
| PGARG |
| Organism | Homo sapiens |
|---|---|
| Rattus norvegicus | |
| Mus musculus |
| MedLine Reference | 10866690 |
|---|---|
| 14570927 | |
| 10698685 | |
| 11953136 | |
| 12707035 |
| LocusLink ID | 57875 |
|---|---|
| 56685 | |
| 93954 | |
| 57375 | |
| 362850 | |
| 51129 |
| FunctionalClass | molecular function unknown |
|---|---|
| enzyme inhibitor |
| GO Cellular Component | extracellular region |
|---|---|
| extracellular space |
| Cell Localization | Extracellular |
|---|
| Pathway | CLADiff |
|---|---|
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| PPARbeta | |
| NR common targets |
| GO Biological Process | angiogenesis |
|---|---|
| cell differentiation | |
| cellular response to starvation | |
| negative regulation of apoptosis | |
| negative regulation of lipoprotein lipase | |
| positive regulation of angiogenesis | |
| positive regulation of lipid metabolism | |
| response to hypoxia | |
| protein oligomerization |
| Group | Ligands |
|---|---|
| CLA Diff |
| Source | Curated |
|---|