| Name | BCL6 |
|---|---|
| Description | B-cell CLL/lymphoma 6 (zinc finger protein 51) |
| Owner | Public |
| URN | urn:agi-llid:604 |
| Connectivity | 48 |
| Notes | The protein encoded by this gene is a zinc finger transcription factor and contains an N-terminal POZ domain. This protein acts as a sequence-specific repressor of transcription, and has been shown to modulate the transcription of START-dependent IL-4 responses of B cells. This protein can interact with a variety of POZ-containing proteins that function as transcription corepressors. This gene is found to be frequently translocated and hypermutated in diffuse large-cell lymphoma (DLCL), and may be involved in the pathogenesis of DLCL. Two alternatively spliced transcript variants that encode the identical protein have been reported for this gene. |
| Hugo ID | 1001 |
| Microarray ID | 215990_s_at |
|---|---|
| 979_g_at | |
| U00115_at | |
| Z79581_at | |
| A_23_P57856 | |
| A_14_P100049 | |
| A_14_P137519 | |
| A_14_P103705 | |
| B85 | |
| OH1274 | |
| 1450381_a_at | |
| u41465_s_at | |
| A_51_P306960 | |
| A_65_P07867 | |
| A_52_P161495 | |
| U00115 | |
| 40091_at | |
| 82601_at | |
| 86652_at | |
| 203140_at |
| Chromosome position | 3q27 |
|---|---|
| 11q23 | |
| 16 13.9 cM |
| GO ID | 0000119 |
|---|---|
| 0000122 | |
| 0003700 | |
| 0005515 | |
| 0005634 | |
| 0006350 | |
| 0006355 | |
| 0006954 | |
| 0008270 | |
| 0008284 | |
| 0046872 | |
| 0003676 | |
| 0003677 | |
| 0007283 | |
| 0016564 | |
| 0043066 |
| Alias | Bcl6_predicted |
|---|---|
| similar to B-cell leukemia/lymphoma VI | |
| similar to B-cell leukemia/lymphoma 6 | |
| LAZ-3 protein | |
| Bcl6 | |
| ZBTB27 | |
| BCL6A | |
| ZBTB27s | |
| cys-his2 zinc finger transcription factor | |
| lymphoma-associated zinc finger gene on chromosome 3 | |
| ZNF51 | |
| B-cell CLL/lymphoma 6 (zinc finger protein 51) | |
| B-cell leukemia/lymphoma 6 | |
| B-cell lymphoma 6 protein | |
| B-cell leukemia/lymphoma VI | |
| lymphoma-associated zinc finger gene on chromosome III | |
| B-cell CLL/lymphoma-6 | |
| Zinc finger protein 51 | |
| B-cell CLL/lymphoma VI |
| Organism | Rattus norvegicus |
|---|---|
| Homo sapiens | |
| Mus musculus |
| MedLine Reference | 10898795 |
|---|---|
| 8220427 | |
| 9171827 | |
| 11092811 | |
| 9632807 |
| LocusLink ID | 104417 |
|---|---|
| 604 | |
| 12053 | |
| 12052 | |
| 303836 |
| FunctionalClass | protein binding |
|---|---|
| transcription factor | |
| zinc ion binding | |
| DNA binding | |
| nucleic acid binding | |
| transcriptional repressor | |
| metal ion binding |
| RGD ID | 1309345 |
|---|
| Hugo Symbol | BCL6 |
|---|
| Unigene ID | Hs.478588 |
|---|---|
| Mm.347398 | |
| Rn.70060 |
| GO Cellular Component | mediator complex |
|---|---|
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | TNFRSF6 -> BCL6 signalling pathway |
|---|---|
| CD28 -> BCL6 signalling pathway | |
| TNFRSF5 -> BCL6 signalling pathway | |
| PTPRC -> BCL6 signalling pathway | |
| B7H2-CD80 | |
| GH1-GHR | |
| GH1-IGF1R | |
| GH1-PRLR | |
| IL4-FCER2 | |
| TNFSF7-CD80 | |
| PPAR all | |
| PPARbeta |
| GO Biological Process | inflammatory response |
|---|---|
| negative regulation of transcription from RNA polymerase II promoter | |
| positive regulation of cell proliferation | |
| regulation of transcription, DNA-dependent | |
| transcription | |
| negative regulation of apoptosis | |
| spermatogenesis | |
| negative regulation of transcription from Pol II promoter |
| Group | Transcription factors |
|---|
| State | B-cell lymphoma 6 protein |
|---|
| State Description | Transcript Variant: This variant (1) contains a different 5' UTR than variant 2. It encodes a protein identical to that encoded by variant 2. |
|---|---|
| Transcript Variant: This variant (2) contains a different 5' UTR than variant 1. It encodes a protein identical to that encoded by variant 1. |
| MGI ID | 107187 |
|---|
| Swiss-Prot Accession | P41182 |
|---|
| OMIM ID | 109565 |
|---|
| Source | Curated |
|---|