| Name | SMARCA4 |
|---|---|
| Description | SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 4 |
| Owner | Public |
| URN | urn:agi-llid:6597 |
| Connectivity | 88 |
| Notes | The protein encoded by this gene is a member of the SWI/SNF family of proteins and is similar to the brahma protein of Drosophila. Members of this family have helicase and ATPase activities and are thought to regulate transcription of certain genes by altering the chromatin structure around those genes. The encoded protein is part of the large ATP-dependent chromatin remodeling complex SNF/SWI, which is required for transcriptional activation of genes normally repressed by chromatin. In addition, this protein can bind BRCA1, as well as regulate the expression of the tumorigenic protein CD44. Alternatively spliced transcripts have been found for this gene, but their full-length natures have not been determined. |
| Hugo ID | 11100 |
| Microarray ID | A_51_P331702 |
|---|---|
| A_51_P479733 | |
| A_65_P20042 | |
| A_52_P147044 | |
| 212520_s_at | |
| 214728_x_at | |
| 214360_at | |
| 213720_s_at | |
| 213719_s_at | |
| 208793_x_at | |
| 32579_at | |
| 57257_s_at | |
| 88069_s_at | |
| 208794_s_at | |
| 215714_s_at | |
| 217656_at | |
| 1569073_x_at | |
| D26156_s_at | |
| U29175_at | |
| rc_aa405496_s_at | |
| rc_aa598648_s_at | |
| A_23_P39034 | |
| A_14_P110032 | |
| A_14_P112104 | |
| A_14_P102576 | |
| A_51_P479737 | |
| A_14_P134129 | |
| A_14_P116631 | |
| A_23_P39040 | |
| A_24_P212851 | |
| 136 | |
| OH7605 | |
| V143 |
| Chromosome position | 19p13.2 |
|---|---|
| 8q13 | |
| 9 6.0 cM |
| GO ID | 0009887 |
|---|---|
| 0006355 | |
| 0016568 | |
| 0000166 | |
| 0003700 | |
| 0003713 | |
| 0004386 | |
| 0005524 | |
| 0005654 | |
| 0006350 | |
| 0006357 | |
| 0016787 | |
| 0005515 | |
| 0005634 | |
| 0006334 | |
| 0008026 | |
| 0016514 | |
| 0016887 | |
| 0003677 | |
| 0001832 | |
| 0001835 | |
| 0003676 | |
| 0006338 |
| Alias | similar to brahma-related protein 1 |
|---|---|
| similar to brahma-related protein I | |
| BRG-1 protein | |
| homeotic gene regulator | |
| HP1-BP72 | |
| hSNF2b | |
| Mitotic growth and transcription activator | |
| Possible global transcription activator SNF2L4 | |
| Smarca4 | |
| SNF2 (sucrose nonfermenting, yeast, homolog)-like 4 | |
| SNF2B | |
| SNF2-beta | |
| sucrose nonfermenting-like 4 | |
| SWI/SNF-related matrix-associated actin-dependent regulator of chromatin a4 | |
| SNF2 (sucrose nonfermenting, yeast, homolog)-like IV | |
| SNF2-like IV | |
| sucrose nonfermenting-like IV | |
| BRM/SWI2-related gene I | |
| brahma-related protein I | |
| brahma-related protein 1 | |
| Brahma protein homolog I | |
| brahma protein-like I | |
| nuclear protein GRB1 | |
| SNF2L4 | |
| nuclear protein GRB I | |
| brahma protein-like 1 | |
| BRM/SWI2-related gene 1 | |
| SNF2-like 4 | |
| Brahma protein homolog 1 |
| Organism | Rattus norvegicus |
|---|---|
| Homo sapiens | |
| Mus musculus |
| MedLine Reference | 11163203 |
|---|---|
| 12466851 | |
| 12889071 | |
| 15565649 | |
| 9603422 | |
| 8208605 | |
| 14676303 |
| LocusLink ID | 20586 |
|---|---|
| 6597 | |
| 171379 |
| FunctionalClass | ATP binding |
|---|---|
| helicase | |
| hydrolase | |
| nucleotide binding | |
| transcription coactivator | |
| transcription factor | |
| ATP-dependent helicase | |
| ATPase | |
| DNA binding | |
| nucleic acid binding | |
| protein binding |
| RGD ID | 621728 |
|---|
| Hugo Symbol | SMARCA4 |
|---|
| Unigene ID | Hs.327527 |
|---|---|
| Mm.286593 | |
| Rn.23417 |
| GO Cellular Component | nucleoplasm |
|---|---|
| SWI/SNF complex | |
| nucleus |
| Cell Localization | Nucleus |
|---|
| Pathway | PLAUR -> SMARCA4 signalling pathway |
|---|---|
| IFNG-HLA-C | |
| IFNG-IFNGR1 | |
| IFNG-IFNGR2 | |
| PPAR all | |
| PPARbeta | |
| ERalpha | |
| GR | |
| NR common regulators |
| GO Biological Process | regulation of transcription from Pol II promoter |
|---|---|
| chromatin modification | |
| organogenesis | |
| regulation of transcription, DNA-dependent | |
| chromatin remodeling | |
| regulation of transcription from RNA polymerase II promoter | |
| transcription | |
| blastocyst growth | |
| blastocyst hatching | |
| nucleosome assembly |
| Group | Transcription factors |
|---|
| MGI ID | 88192 |
|---|
| Swiss-Prot Accession | P51532 |
|---|
| OMIM ID | 603254 |
|---|
| Source | Curated |
|---|