Protein : FABP5


Name	FABP5
Description	fatty acid binding protein 5 (psoriasis-associated)
Owner	Public
URN	urn:agi-llid:2171
Connectivity	3
Notes	This gene encodes the fatty acid binding protein found in epidermal cells, and was first identified as being upregulated in psoriasis tissue. Fatty acid binding proteins are a family of small, highly conserved, cytoplasmic proteins that bind long-chain fatty acids and other hydrophobic ligands. It is thought that FABPs roles include fatty acid uptake, transport, and metabolism. S100A7 expression appears to stabilize epidermal fatty acid binding protein level in keratinocytes. Solution structure and backbone dynamics. The overexpression of FABP in cultured senescent dermal microvascular endothelial cells is closely related to skin aging.


Chromosome position	8q21.13
	3 A1-3


Alias	EFABP
	E-FABP
	Fabp5
	fatty acid binding protein 5
	fatty acid binding protein 5 (psoriasis-associated)
	fatty acid binding protein 5, epidermal
	Fatty acid-binding protein, epidermal
	keratinocyte lipid binding protein
	PAFABP
	PA-FABP
	Psoriasis-associated fatty acid-binding protein homolog
	K-FABP
	KFABP
	keratinocyte fatty acid binding protein
	fatty acid binding protein V
	Fabpe E-FABP
	Klbp
	psoriasis-associated fatty acid binding protein
	Unknown Klbp, keratinocyte lipid binding protein
	PA-FABPs


GO Cellular Component	cytoplasm


Cell Localization	Cytoplasm


Pathway	PPAR all
	PPARbeta


GO Biological Process	epidermis development
	lipid metabolism
	transport
	response to wounding
	glucose metabolism
	glucose transport
	phosphatidylcholine biosynthesis


Source	Curated