| Name | NCOR1 |
|---|---|
| Description | nuclear receptor co-repressor 1 |
| Owner | Public |
| URN | urn:agi-llid:9611 |
| Connectivity | 98 |
| Notes | This gene encodes a protein that mediates ligand-independent transcription repression of thyroid-hormone and retinoic-acid receptors by promoting chromatin condensation and preventing access of the transcription machinery. It is part of a complex which also includes histone deacetylases and transcriptional regulators similar to the yeast protein Sin3p. This gene is located between the Charcot-Marie-Tooth and Smith-Magenis syndrome critical regions on chromosome 17. An alternatively spliced transcript variant has been described, but its full length sequence has not been determined. |
| Hugo ID | 7672 |
| Microarray ID | A_43_P15619 |
|---|---|
| 1423201_at | |
| 1423202_a_at | |
| u35312_s_at | |
| A_51_P489043 | |
| A_52_P561934 | |
| A_51_P457744 | |
| 200854_at | |
| 200856_x_at | |
| 200855_at | |
| 234313_at | |
| 39722_at | |
| 63388_at | |
| 75470_at | |
| 200857_s_at | |
| 217152_at | |
| 1568748_at | |
| 243682_at | |
| U37146_at | |
| rc_aa156336_at | |
| rc_n33258_at | |
| rc_z39406_at | |
| A_23_P141645 | |
| A_14_P100615 | |
| A_14_P104592 | |
| A_14_P133842 | |
| A_14_P122302 | |
| A_14_P117835 | |
| A_14_P100903 | |
| A_24_P204214 | |
| A_23_P141651 | |
| A_24_P237661 | |
| A_24_P911017 | |
| OH4650 | |
| AH0834 |
| Chromosome position | 17p11.2 |
|---|---|
| 11 B2 |
| GO ID | 0003677 |
|---|---|
| 0003714 | |
| 0005634 | |
| 0006355 | |
| 0006366 | |
| 0045449 | |
| 0004872 | |
| 0005515 | |
| 0006350 | |
| 0016481 | |
| 0016564 | |
| 0045892 |
| Alias | similar to Nuclear receptor co-repressor 1 (N-CoR1) (N-CoR) |
|---|---|
| GNB:3510603 | |
| hCIT529I10 | |
| hN-CoR | |
| N-Cor/SMRT corepressor, Rip13 | |
| NCOR I | |
| N-CoR I | |
| TRAC I | |
| N-CoR Is | |
| N-CoR1s | |
| retinoid x receptor interacting protein 13 | |
| retinoid x receptor interacting protein XIII | |
| mKIAA1047 | |
| nuclear receptor co-repressor 1 | |
| RIKEN cDNA A230020K14 gene | |
| N-CoR1 | |
| THYROID HORMONE- AND RETINOIC ACID RECEPTOR-ASSOCIATED COREPRESSOR 1 | |
| KIAA1047 | |
| NCOR | |
| N-CoR | |
| RIP13 | |
| Rxrip13 | |
| TRAC1 | |
| A230020K14Rik | |
| Nuclear receptor co-repressor 1 (N-CoR1) (N-CoR) | |
| N-Cor/SMRT corepressor, Rip | |
| nuclear receptor co-repressor N-CoR | |
| THYROID HORMONE- AND RETINOIC ACID RECEPTOR-ASSOCIATED COREPRESSOR I | |
| nuclear receptor co-repressor I | |
| NCOR1 |
| Organism | Rattus norvegicus |
|---|---|
| Homo sapiens | |
| Mus musculus |
| MedLine Reference | 7566114 |
|---|---|
| 11891224 | |
| 15371360 | |
| 15681609 |
| LocusLink ID | 113950 |
|---|---|
| 319274 | |
| 9611 | |
| 54299 | |
| 20185 | |
| 320690 |
| FunctionalClass | protein binding |
|---|---|
| receptor | |
| transcription corepressor | |
| transcriptional repressor | |
| DNA binding |
| RGD ID | 3612 |
|---|
| Hugo Symbol | NCOR1 |
|---|
| Unigene ID | Mm.271814 |
|---|---|
| Rn.24948 | |
| Hs.462323 |
| GO Cellular Component | nucleus |
|---|
| Cell Localization | Nucleus |
|---|
| Pathway | CCL19-CD44 |
|---|---|
| FGF4-CD44 | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-TFRC | |
| NRG1-CD44 | |
| PXR | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| PPARbeta | |
| LXR | |
| AR | |
| ERalpha | |
| GR | |
| COUP-TF | |
| Nurr1 | |
| TR | |
| NR common regulators |
| GO Biological Process | transcription from Pol II promoter |
|---|---|
| regulation of transcription | |
| regulation of transcription, DNA-dependent | |
| transcription from RNA polymerase II promoter | |
| negative regulation of transcription | |
| negative regulation of transcription, DNA-dependent | |
| transcription |
| Group | Transcription factors |
|---|
| MGI ID | 1349717 |
|---|
| Swiss-Prot Accession | O75376 |
|---|
| OMIM ID | 600849 |
|---|
| Source | Curated |
|---|