| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-llid:5468:out-urn:agi-go:0008009::negative |
| Entities | PPARG ---| chemokine activity |
| References | 5 |
| Connectivity | 2 |
| Effect | negative |
| Tissue | endometrial |
|---|---|
| MedLine Reference | 11932328:9 |
| Sentence | The use of PPAR-gamma ligands to reduce chemokine production and inflammation may be a productive strategy for future therapy of endometrial disorders, such as endometriosis. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | M/M |
| CellType | macrophage |
| MedLine Reference | 12110006:0 |
| Sentence | Activators of peroxisome proliferator activated receptor gamma (PPARgamma) have been shown to modulate chemokine expression in isolated monocytes/macrophages (M/M) and to exert anti-inflammatory effects in some models of experimental inflammatory diseases. |
| Journal | Circulation Res |
|---|---|
| CellType | monocyte |
| Journal Reference | v93 i4 p311 (2003) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/93/4/311 |
| MedLine Reference | 12881478:1195 |
| Sentence | Indeed, we have shown that NF-kappaB inhibition and PPARgamma activation obviously inhibit Hcy-induced ROS formation and chemokine production. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Immunol |
| CellType | macrophage |
| Journal Reference | v171 i2 p979 (2003) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/171/2/979 |
| MedLine Reference | 12847270:1035 |
| Sentence | In addition, PPARgamma activators were reported to inhibit IFN-gamma-induced mRNA and protein expression of CXC chemokines ( 20 ). |
| CellLineName | HASM |
|---|---|
| MedLine Reference | 15531761:6 |
| Sentence | Our data suggest that chemokine expression in HASM cells is differentially regulated by PPARgamma agonists and that the interaction between PPARgamma and GR may be responsible for the additive and synergistic inhibition of chemokine expression by PPARgamma agonists, glucocorticoids, and beta(2)-agonists, particularly the chromatin-dependent suppression of eotaxin gene transcription. |