| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:87893-55-8:out-urn:agi-llid:5468::positive |
| Entities | PPARG <+-- 15d-PGJ-2 |
| References | 12 |
| Connectivity | 2 |
| Effect | positive |
| Journal | Cancer Res |
|---|---|
| Journal Reference | v64 i15 p5162 (2004) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/64/15/5162 |
| Organ | colon |
| MedLine Reference | 15289320:1038 |
| Sentence | The cyclopentenone prostaglandin 15d-PGJ2, the PPARgamma antagonist (GW-9662), the prostaglandin E2 (PGE2) enzyme immunoassay kit, and the monoclonal COX-2 antibody were from Cayman Chemical (Ann Arbor, MI). |
| Organism | Mus musculus |
|---|---|
| CellType | osteoblast |
| MedLine Reference | 12878983:8 |
| Sentence | Our findings indicate that 15d-PGJ2-induced PPAR-gamma abrogates beta-glycerophosphate-activated Cbfa1 and NF-kappaB. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | RMC |
| Tissue | mesangia |
| MedLine Reference | 15629510:8 |
| Sentence | In trans-activation assays, celecoxib acted as a PPARgamma agonist whereas albumin inhibited PPARgamma as well as 15d-PGJ2-induced PPARgamma activation. |
| Journal | J. Neurochem |
|---|---|
| CellType | macrophage |
| Journal Link | http://www.blackwell-synergy.com/links/doi/10.1046/j.1471-4159.2001.00461.x/full/ |
| MedLine Reference | 3476517326 |
| Sentence | This was clearly demonstrated by findings that 15d-PGJ 2 reduced iNOS expression in RAW macrophages (which did not express PPARgamma) if they were first transfected with a PPARgamma expression plasmid (Ricote et al., 1998 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v64 i5 p1169 (2003) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/64/5/1169 |
| MedLine Reference | 14573767:1325 |
| Sentence | In this study, 15d-PGJ2 and ciglitazone also inhibited the NF-AT binding activities of NF-AT in vitro ( Fig. 5 ), suggesting that the PPAR-gamma/NF-AT complex was unable to recognize NF-AT sites. |
| Journal | AJRCMB |
|---|---|
| Journal Reference | v24 i6 p688 (2001) |
| Tissue | epithelia |
| Journal Link | http://ajrcmb.atsjournals.org/cgi/content/full/24/6/688 |
| Organ | lung |
| MedLine Reference | 11415933:1167 |
| Sentence | In our study, we demonstrate that stimulating airway epithelial PPAR-gamma using either 15d-PGJ2 or a synthetic ligand specific for PPAR-gamma, ciglitazone, resulted in the transactivation of a PPAR-dependent promoter, (AOx)3-TK-luciferase. |
| CellLineName | THP I |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i2 p1241 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/2/1241 |
| MedLine Reference | 10625669:1105 |
| Sentence | Both OxLDL and 15d-PGJ 2 activate PPAR-gamma and increase transcription of PPAR-gamma-responsive genes ( 22 , 23 ). |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v275 i36 p28173 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/36/28173 |
| MedLine Reference | 10866999:1221 |
| Sentence | Some NSAIDs and 15d-PGJ 2 , which are known to activate PPARgamma, induce COX-2 expression in the absence of other inducers of COX-2 expression (Figs. 3-5 ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | C2C12 |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i41 p38297 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/41/38297 |
| MedLine Reference | 11477074:1292 |
| Sentence | In agreement with the latter observation, we found that both 15d-PGJ2 and ciglitazone enhanced the expression of PPARgamma mRNA in C2C12 cells consistent with the suggestion that PPARgamma ligands may participate in a positive feedback mechanism that elevates PPARgamma mRNA expression. |
| Organ | hypothalamic |
|---|---|
| MedLine Reference | 2178708108 |
| Sentence | In addition to altering the NF-kappa B pathway and consequently the expression of COX-2, 15d-PGJ2 can alter the p44/p42 MAPK pathway and enhance the expression of PPARgamma (Prusty et al., 2002 ). |
| Organism | Mus musculus |
|---|---|
| Tissue | marrow |
| MedLine Reference | 11728175:7 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Immunol |
| CellType | monocyte |
| Journal Reference | v171 i12 p6827 (2003) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/171/12/6827 |
| MedLine Reference | 14662889:1243 |