| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:74772-77-3:out-urn:agi-llid:5468::positive |
| Entities | PPARG <+-- ciglitazone |
| References | 15 |
| Connectivity | 2 |
| Effect | positive |
| Journal | AJRCMB |
|---|---|
| Journal Reference | v24 i6 p688 (2001) |
| Tissue | epithelia |
| Journal Link | http://ajrcmb.atsjournals.org/cgi/content/full/24/6/688 |
| Organ | lung |
| MedLine Reference | 11415933:1167 |
| Sentence | In our study, we demonstrate that stimulating airway epithelial PPAR-gamma using either 15d-PGJ2 or a synthetic ligand specific for PPAR-gamma, ciglitazone, resulted in the transactivation of a PPAR-dependent promoter, (AOx)3-TK-luciferase. |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v274 i24 p17042 (1999) |
| Tissue | endothelial |
| Journal Link | http://www.jbc.org/cgi/content/full/274/24/17042 |
| MedLine Reference | 10358055:1010 |
| Sentence | Ciglitizone, a selective activator of PPARgamma, also induced transcriptional activation and endothelial cell apoptosis. |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 10916284:0 |
| Sentence | Ciglitazone, an antidiabetic agent of the thiazolidinedione family, is known to be an activator of the peroxisome-proliferator activator receptor (PPAR)-gamma. |
| CellLineName | PM |
|---|---|
| CellType | macrophage |
| MedLine Reference | 12195700:4 |
| Sentence | Ciglitazone activates PPAR gamma as shown by a novel surface plasmon resonance analysis and inhibits the plasmin-induced activation of NF-kappa B and AP-1. |
| Organism | Mus musculus |
|---|---|
| CellLineName | MTS |
| MedLine Reference | 12697971:7 |
| Sentence | On the other hand, ciglitazone activated the endogenous PPAR-gamma in MMCs. |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | mucosa |
| Organ | gastric |
| MedLine Reference | 12749691:2 |
| Sentence | Using gastric mucosal cells in culture, we show that activation of PPARgamma with a specific synthetic agonist, ciglitazone, prevents in a dose-dependent fashion (up to 90.2%) the LPS-induced reduction in mucin synthesis, and the effect is reflected in a marked decrease in the LPS-induced apoptosis (72.4%), NO generation (80.1%), and the expression of NOS-2 activity (90%). |
| Organism | Mus musculus |
|---|---|
| CellType | keratinocyte |
| MedLine Reference | 15245430:1 |
| Sentence | Here we demonstrate that treatment of cultured human keratinocytes with ciglitazone, a PPAR-gamma activator, increases involucrin and transglutaminase 1 mRNA levels. |
| Organ | kidney |
|---|---|
| MedLine Reference | 15149321:8 |
| Sentence | The PPAR gamma agonists 15-deoxy-Delta(12,14)-prostaglandin J(2) (15d-PGJ(2)), ciglitazone, and troglitazone stimulated significant transcriptional activation and phosphorylation of PPAR gamma. |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | saliva |
| MedLine Reference | 15185749:2 |
| Sentence | We show that activation of PPARgamma with a specific agonist, ciglitazone, prevents the LPS-induced reduction in mucin synthesis, and the effect is reflected in a marked decrease in apoptosis, caspase-3 activity and NO generation. |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | mucosa |
| Organ | gastric |
| MedLine Reference | 15265318:2 |
| Sentence | Using gastric mucosal cells in culture, we show that activation of PPARgamma with a specific agonist, ciglitazone, prevents the LPS-induced reduction in mucin synthesis, and the effect is reflected in a marked decrease in apoptosis, caspase-3 activity and NO generation. |
| Journal | Mol. Cell. Biol |
|---|---|
| Journal Reference | v24 i19 p8691 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/19/8691 |
| MedLine Reference | 15367687:1142 |
| Journal | Circulation Res |
|---|---|
| Journal Reference | v94 i11 p1515 (2004) |
| Tissue | vasculature |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/94/11/1515 |
| MedLine Reference | 15117825:1095 |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v64 i5 p1169 (2003) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/64/5/1169 |
| MedLine Reference | 14573767:1325 |
| Organism | Mus musculus |
|---|---|
| CellLineName | C2C12 |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i41 p38297 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/41/38297 |
| MedLine Reference | 11477074:1292 |
| CellLineName | HT 29 |
|---|---|
| MedLine Reference | 14587029:6 |