| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:67254-79-9:out-urn:agi-llid:5468::positive |
| Entities | fatty acid --+> PPARG |
| References | 21 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| CellLineName | NIH 3T3 |
| Journal | J. Biol. Chem |
| CellType | fibroblast |
| Journal Reference | v274 i31 p21920 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/31/21920 |
| MedLine Reference | 10419513:1041 |
| Sentence | First, it has been shown that PPARgamma is not directly activated by fatty acids ( 20 , 21 ), whereas LCFAs are strong activators of PPARdelta ( 11 , 14 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i29 p22435 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/29/22435 |
| Organ | heart |
| MedLine Reference | 10801895:1012 |
| Sentence | RESULTS DISCUSSION REFERENCES Peroxisome proliferator-activated receptor gamma (PPARgamma) is a member of the nuclear receptor superfamily that is activated by binding certain fatty acids, eicosanoids, and insulin-sensitizing thiazolidinediones (TZD ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v276 i47 p43509 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/43509 |
| MedLine Reference | 11546778:1205 |
| Sentence | The LXRalpha gene was also recently shown to be directly regulated by peroxisome proliferator-activated receptor gamma, which is activated by fatty acids and their metabolites ( 38 ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i23 p21058 (2003) |
| Tissue | fat |
| Journal Link | http://www.jbc.org/cgi/content/full/278/23/21058 |
| MedLine Reference | 12649288:1338 |
| Sentence | PPARgamma is a member of the steroid hormone receptor family expressed in adipose tissue and is activated by fatty acids. |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v278 i35 p33268 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/35/33268 |
| MedLine Reference | 12794068:1312 |
| Sentence | PPARgamma is a nuclear hormone receptor that is activated by fatty acids and other intracellular lipids ( 49 ). |
| CellType | monocyte |
|---|---|
| MedLine Reference | 9794815:2 |
| Sentence | Polyunsaturated fatty acids and eicosanoids bind and activate PPARgamma, suggesting that these lipids may serve as hormonal regulators of a variety of biological processes. |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 10725292:0 |
| Sentence | Peroxisome proliferator-activated receptor-gamma (PPARgamma) is activated by fatty acids, eicosanoids, and insulin-sensitizing thiazolidinediones (TZDs). |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 11739861:0 |
| Sentence | Oxidized LDL (oxLDL) and its component hydroxy fatty acids were shown to activate peroxisome proliferator-activating receptor alpha (PPARalpha) and gamma (PPARgamma). |
| CellLineName | bewo |
|---|---|
| Organ | placenta |
| MedLine Reference | 12538089:3 |
| Sentence | In addition, these fatty acids also increased expression of PPARgamma in these cells, suggesting a putative relationship between free fatty acid generated by acyl-CoA thioesterase and expression of PPARgamma. |
| Organism | Mus musculus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 15015141:2 |
| Sentence | In turn, FABP4 binds fatty acids and transports them to the nucleus where the FABP4/fatty acid complex activates PPARgamma in a positive feedback loop. |
| Journal | Nutrition |
|---|---|
| Journal Reference | v133 i10 p3058 (2003) |
| Journal Link | http://www.nutrition.org/cgi/content/full/133/10/3058 |
| MedLine Reference | 14519784:1103 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | PNAS |
| Journal Reference | v100 i16 p9476 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/16/9476 |
| MedLine Reference | 12869692:1105 |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v277 i2 p1586 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/2/1586 |
| MedLine Reference | 11696534:1024 |
| Organism | Mus musculus |
|---|---|
| Journal | Carcinogenesis |
| CellType | adipocyte |
| Journal Reference | v20 i10 p1905 (1999) |
| Tissue | fat |
| Journal Link | http://carcin.oupjournals.org/cgi/content/full/20/10/1905 |
| MedLine Reference | 10506103:1035 |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v141 i11 p4021 (2000) |
| Tissue | fat |
| Journal Link | http://endo.endojournals.org/cgi/content/full/141/11/4021 |
| Organ | spleen |
| MedLine Reference | 11089532:1033 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v142 i3 p1269 (2001) |
| Tissue | fat |
| Journal Link | http://endo.endojournals.org/cgi/content/full/142/3/1269 |
| MedLine Reference | 11181544:1039 |
| Organism | Mus musculus |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v283 i2 pG266 (2002) |
| Tissue | fat |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/283/2/G266 |
| Organ | colon |
| MedLine Reference | 12121872:1046 |
| Journal | Endocrin. Metabol |
|---|---|
| Journal Reference | v286 i4 pE560 (2004) |
| Tissue | islet |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/286/4/E560 |
| MedLine Reference | 14625208:1115 |
| Journal | Endocrinology |
|---|---|
| Journal Reference | v145 i8 p3563 (2004) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/8/3563 |
| Organ | pancreas |
| MedLine Reference | 15265823:1047 |
| Tissue | endocrine |
|---|---|
| Organ | pancreas |
| MedLine Reference | 11043863:1 |
| Tissue | fat |
|---|---|
| MedLine Reference | 11395411:0 |