| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:97322-87-7:out-urn:agi-llid:5468::positive |
| Entities | PPARG <+-- troglitazone |
| References | 30 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 12727930:3 |
| Sentence | PPAR-gamma activating thiazolidinediones (TZDs) rosiglitazone and troglitazone induced G(0)-G(1) cell-cycle arrest and apoptosis in human, rat somatolactotroph, and murine gonadotroph pituitary tumor cells, and suppressed in vitro hormone secretion. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | VSMCs |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i52 p48950 (2001) |
| Tissue | smooth muscle |
| Journal Link | http://www.jbc.org/cgi/content/full/276/52/48950 |
| MedLine Reference | 11687581:1024 |
| Sentence | PPARgamma is activated by a natural ligand, 15-deoxy-Delta 12,14 -prostaglandin J 2 (15-d-PGJ2 ) ( 5 ), and synthetic ligands, thiazolidinediones (TZDs) ( 6 ) such as pioglitazone (Pio ) and troglitazone (Tro ). |
| Organism | Mus musculus |
|---|---|
| CellLineName | 3T3 L1 |
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v278 i30 p28181 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/30/28181 |
| MedLine Reference | 12732648:1183 |
| Sentence | The significance of this observation is not known, and yet troglitazone did cause PPAR-gamma activation as evidenced by the robust induction of several PPAR-gamma target genes including PEPCK ( Fig. 2 E ). |
| Journal | JPET |
|---|---|
| Journal Reference | v302 i1 p18 (2002) |
| Tissue | synovial |
| Journal Link | http://jpet.aspetjournals.org/cgi/content/full/302/1/18 |
| MedLine Reference | 12065695:1211 |
| Sentence | We also demonstrated that rheumatoid synovial cells expressed PPARgamma mRNA and that troglitazone and 15dPGJ2 increased the activation of PPARgamma, reduced cell proliferation, and induced apoptosis in the synovial cells. |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | fat |
| MedLine Reference | 9502777:0 |
| Sentence | Troglitazone (CS-045) is one of the thiazolidinediones that activate the peroxisome proliferator-activated receptor gamma (PPARgamma), which is expressed primarily in adipose tissues. |
| CellType | macrophage |
|---|---|
| MedLine Reference | 9665460:7 |
| Sentence | Stimulation of PPARgamma with troglitazone or 15-deoxy-delta12,14-prostaglandin J2 in human monocyte-derived macrophages inhibited MMP-9 gelatinolytic activity in a concentration-dependent fashion as revealed by zymography. |
| Organism | Mus musculus |
|---|---|
| Tissue | muscle |
| MedLine Reference | 9709955:5 |
| Sentence | In summary, we showed that troglitazone markedly induces PPARgamma, ALBP, and mFABP mRNA abundance in muscle cultures from both nondiabetic and type II diabetic subjects. |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 10724355:3 |
| Sentence | Troglitazone (Tro), a new anti-diabetic drug, is a thiazolidinedione (TZD) which promotes adipocyte differentiation by activating peroxisome proliferator activated receptor gamma (PPARgamma). |
| Organism | Mus musculus |
|---|---|
| CellLineName | T24 |
| MedLine Reference | 10935488:7 |
| Sentence | Troglitazone also induced an endogenous PPARgamma target gene in T24 cells, adipocyte-type fatty acid binding protein (A-FABP), the expression of which correlates with bladder cancer differentiation. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | PC12h |
| MedLine Reference | 10222233:4 |
| Sentence | However, troglitazone, an activator of peroxisome proliferator-activated receptorgamma (PPARgamma), and other PG's including PGA1, PGA2 and PGD2 did not promote neurite outgrowth. |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 10503944:1 |
| Organ | kidney |
|---|---|
| MedLine Reference | 15149321:8 |
| Organism | Rattus norvegicus |
|---|---|
| Organ | heart |
| MedLine Reference | 15528232:2 |
| Organism | Mus musculus |
|---|---|
| CellLineName | PC |
| Journal | Cancer Res |
| Journal Reference | v63 i17 p5274 (2003) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/63/17/5274 |
| MedLine Reference | 14500358:1178 |
| CellLineName | SW 480 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i34 p35583 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/34/35583 |
| MedLine Reference | 15190077:1286 |
| Journal | Circulation Res |
|---|---|
| CellType | monocyte |
| Journal Reference | v93 i4 p271 (2003) |
| Journal Link | http://circres.ahajournals.org/cgi/content/full/93/4/271 |
| MedLine Reference | 12933697:1036 |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| CellType | adipocyte |
| Journal Reference | v145 i5 p2346 (2004) |
| Tissue | fat |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/5/2346 |
| MedLine Reference | 14726448:1032 |
| Organism | Mus musculus |
|---|---|
| Journal | Heart Circul |
| Journal Reference | v283 i3 pH949 (2002) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/283/3/H949 |
| MedLine Reference | 12181123:1222 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v285 i1 pG20 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/285/1/G20 |
| Organ | liver |
| MedLine Reference | 12660143:1199 |
| Tissue | fat |
|---|---|
| MedLine Reference | 11357475:7 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11344222:6 |
| CellLineName | U 937 |
|---|---|
| CellType | monocyte |
| MedLine Reference | 15680279:4 |
| CellLineName | COS I |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v64 i2 p355 (2003) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/64/2/355 |
| MedLine Reference | 12869640:1114 |
| Organism | Mus musculus |
|---|---|
| Journal | Renal Phys |
| Journal Reference | v281 i6 pF1036 (2001) |
| Tissue | mesangia |
| Journal Link | http://ajprenal.physiology.org/cgi/content/full/281/6/F1036 |
| MedLine Reference | 11704554:1191 |
| Organism | Mus musculus |
|---|---|
| Journal | Renal Phys |
| Journal Reference | v282 i4 pF639 (2002) |
| Tissue | mesangia |
| Journal Link | http://ajprenal.physiology.org/cgi/content/full/282/4/F639 |
| MedLine Reference | 11880325:1166 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v279 i8 p6883 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/8/6883 |
| MedLine Reference | 14662774:1280 |
| Organism | Mus musculus |
|---|---|
| CellLineName | C2C12 |
| Tissue | muscle |
| Organ | kidney |
| MedLine Reference | 10871190:3 |
| MedLine Reference | 12416897:0 |
|---|
| MedLine Reference | 12475986:8 |
|---|
| MedLine Reference | 15175945:0 |
|---|