| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:111025-46-8:out-urn:agi-llid:5468::positive |
| Entities | PPARG <+-- pioglitazone |
| References | 11 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| CellLineName | NIH 3T3 |
| Journal | Genes & Dev |
| Journal Reference | v11 i15 p1987 (1997) |
| Tissue | fat |
| Journal Link | http://www.genesdev.org/cgi/content/full/11/15/1987 |
| MedLine Reference | 9271121:1046 |
| Sentence | Pioglitazone stimulates growth arrest as well as adipose differentiation of NIH-3T3 cells expressing PPARgamma ectopically. |
| Organism | Rattus norvegicus |
|---|---|
| CellLineName | OP |
| Tissue | medulla |
| Organ | renal |
| MedLine Reference | 14638618:3 |
| Sentence | Pioglitazone treatment increased PPARgamma expression and activity in OP rats, suggesting a possible direct ligand-related effect of pioglitazone. |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 12384507:0 |
| Sentence | Pioglitazone, like other thiazolidinediones, is an insulin-sensitizing agent that activates the peroxisome proliferator-activated receptor gamma and influences the expression of multiple genes involved in carbohydrate and lipid metabolism. |
| CellLineName | THP I |
|---|---|
| CellType | macrophage |
| MedLine Reference | 15279882:3 |
| Sentence | Prostaglandin F2alpha (PGF2alpha), a PARgamma inhibitor, abrogated the up-regulation of PAF-AH mRNA by pioglitazone, suggesting that PPARgamma activation is involved in the induction of PAF-AH by pioglitazone. |
| Organism | Rattus norvegicus |
|---|---|
| Organ | heart |
| MedLine Reference | 15737646:4 |
| Sentence | Pioglitazone increased body weight and improved metabolic control, cardiac PPARgamma, glut-4, and alpha-MHC expression levels in diabetic ZDF rats. |
| Journal | Mol. Pharm |
|---|---|
| Journal Reference | v63 i2 p401 (2003) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/63/2/401 |
| Organ | liver |
| MedLine Reference | 12527812:1034 |
| Sentence | TRO-induced apoptosis does not seem to be mediated through PPARgamma activation, because other structural analogs of TRO, such as RSG and pioglitazone, both of which stimulate the PPARgamma, do not seem to cause increased cell death (Day, 1999 ; Lebovitz et al., 2002 ). |
| Journal | Cell |
|---|---|
| Journal Reference | v87 i3 p377 (1996) |
| Journal Link | http://www.cell.com/cgi/content/full/87/3/377 |
| MedLine Reference | 2589919970 |
| Sentence | In fact, the anti-diabetic TZDs BRL49653 and pioglitazone elicit a strong activation of PPARgamma, with relatively little activity on PPARalpha and delta ( Lehmann et al., 1995 ; Forman et al., 1995 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v141 i11 p4021 (2000) |
| Tissue | fat |
| Journal Link | http://endo.endojournals.org/cgi/content/full/141/11/4021 |
| Organ | spleen |
| MedLine Reference | 11089532:1033 |
| Sentence | On the other hand, PPAR-gamma is activated by polyunsaturated fatty acids, prostaglandin J2, and the thiazolidinedione group of drugs that includes troglitazone, rosiglitazone, and pioglitazone ( 1 , 2 ). |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 9790963:0 |
| Sentence | Pioglitazone is a thiazolidinedione drug (TZD) which potently and specifically stimulates peroxisome proliferator-activated receptor gamma (PPAR gamma) and sensitizes cells to insulin. |
| MedLine Reference | 10983737:1 |
|---|---|
| Sentence | Pioglitazone activates the nuclear peroxisome proliferator activated receptor-gamma (PPAR-gamma), which leads to the increased transcription of various proteins regulating glucose and lipid metabolism. |
| MedLine Reference | 11712410:2 |
|---|