| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:122320-73-4:out-urn:agi-llid:5468::positive |
| Entities | PPARG <+-- rosiglitazone |
| References | 19 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i15 p12503 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/15/12503 |
| MedLine Reference | 11877384:1093 |
| Sentence | As expected, rosiglitazone (60 n M ) activated PPARgamma, but notably this activation was further enhanced by LG754 . |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v278 i39 p37672 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/39/37672 |
| MedLine Reference | 12821652:1161 |
| Sentence | These morphological changes were accompanied by a pronounced induction of mRNA levels of the adipocyte-specific marker, and PPARgamma target gene, aP2, whose expression was strongly induced by rosiglitazone and Rev-Erbalpha ( Fig. 7 ). |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v279 i33 p34411 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/33/34411 |
| MedLine Reference | 15190076:1132 |
| Sentence | In differentiated human SGBS adipocytes, both rosiglitazone and L165041 caused an induction of FIAF mRNA ( Fig. 2, B and C , respectively), indicating that both PPARgamma and PPARbeta/delta regulate FIAF expression in human adipocytes. |
| Organism | Rattus norvegicus |
|---|---|
| Tissue | smooth muscle |
| Organ | aorta |
| MedLine Reference | 12694805:4 |
| Sentence | In the presence of the non-thiazolidinedione partial PPARgamma agonist, the transcriptional activity of the full agonist, rosiglitazone, was blunted, indicating that the non-thiazolidinedione partial PPARgamma agonist inhibits rosiglitazone-induced PPARgamma activity. |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 12727930:3 |
| Sentence | PPAR-gamma activating thiazolidinediones (TZDs) rosiglitazone and troglitazone induced G(0)-G(1) cell-cycle arrest and apoptosis in human, rat somatolactotroph, and murine gonadotroph pituitary tumor cells, and suppressed in vitro hormone secretion. |
| CellLineName | ec |
|---|---|
| Organ | umbilical vein |
| MedLine Reference | 14971050:6 |
| Sentence | EMSA demonstrated an activation of PPARgamma by PGJ2 and rosiglitazone. |
| Organism | Mus musculus |
|---|---|
| CellLineName | sw 1990 |
| CellType | tumor model |
| MedLine Reference | 12921608:4 |
| Sentence | Pancreatic cancer xenograft tumor model was established in nude mice by inoculating SW1990 cells subcutaneously and rosiglitazone, a PPARgamma activator, was administered via water drinking in experimental group. |
| Organism | Mus musculus |
|---|---|
| Journal | Mol. Endocrin |
| Journal Reference | v17 i12 p2477 (2003) |
| Tissue | skeletal muscle |
| Journal Link | http://mend.endojournals.org/cgi/content/full/17/12/2477 |
| MedLine Reference | 14525954:1328 |
| Sentence | Rosiglitazone-mediated activation of PPARgamma induces gene expression associated with glucose uptake, FA synthesis, and lipid storage, consistent with previous studies. |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v142 i7 p3207 (2001) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/142/7/3207 |
| MedLine Reference | 11416043:1011 |
| Sentence | PD068235 inhibited rosiglitazone-dependent PPARgamma transcriptional activity with an IC50 of 0.8 A?Aµ M and rosiglitazone-stimulated in vitro coactivator association. |
| Tissue | mammary |
|---|---|
| MedLine Reference | 15533890:4 |
| Sentence | Controversially, GW9662 prevented rosiglitazone-mediated PPARgamma activation, but enhanced rather than reversed rosiglitazone-induced growth inhibition. |
| Journal | Endocrin. Metabol |
|---|---|
| Journal Reference | v286 i4 pE560 (2004) |
| Tissue | islet |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/286/4/E560 |
| MedLine Reference | 14625208:1115 |
| Tissue | fat |
|---|---|
| MedLine Reference | 15277403:11 |
| Tissue | endothelial |
|---|---|
| MedLine Reference | 15498928:3 |
| Organism | Mus musculus |
|---|---|
| CellLineName | TS |
| Journal | Mol. Cell. Biol |
| Journal Reference | v24 i24 p10661 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/24/10661 |
| MedLine Reference | 15572671:1089 |
| Journal | Endocrin. Metabol |
|---|---|
| Journal Reference | v284 i5 pE1049 (2003) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/284/5/E1049 |
| MedLine Reference | 12554596:1081 |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v141 i11 p4021 (2000) |
| Tissue | fat |
| Journal Link | http://endo.endojournals.org/cgi/content/full/141/11/4021 |
| Organ | spleen |
| MedLine Reference | 11089532:1033 |
| Organism | Mus musculus |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v287 i2 pG452 (2004) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/287/2/G452 |
| MedLine Reference | 15246971:1027 |
| Organism | Rattus norvegicus |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i28 p25651 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/28/25651 |
| MedLine Reference | 11373275:1032 |
| CellLineName | HT 29 |
|---|---|
| MedLine Reference | 15342379:1 |