| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:167869-21-8:out-urn:agi-llid:5468::negative |
| Entities | PPARG |--- PD98059 |
| References | 5 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Mus musculus |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v140 i1 p392 (1999) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/140/1/392 |
| MedLine Reference | 9886850:1085 |
| Sentence | As previously reported ( 15 ), this treatment caused a significant increase in PPARgamma phosphorylation that was completely blocked by PD98059 (Fig. 2a , lanes 3 and 4). |
| CellLineName | THP I |
|---|---|
| Journal | J. Biol. Chem |
| CellType | macrophage |
| Journal Reference | v275 i2 p1241 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/2/1241 |
| MedLine Reference | 10625669:1126 |
| Sentence | In contrast, two MAP kinase inhibitors, PD98059 and UO126, significantly blocked PPAR-gamma phosphorylation (Fig. 6 B ). |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v277 i48 p46226 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/48/46226 |
| MedLine Reference | 12270934:1157 |
| Sentence | Inhibition of this activity by exposure of preadipocytes to the MEK1 inhibitors U0126 or PD98059 significantly attenuates expression of C/EBPalpha and PPARgamma without affecting C/EBPeta expression. |
| Tissue | mesangia |
|---|---|
| MedLine Reference | 15522842:12 |
| Sentence | PPARgamma expression induced by 9HODE was also reduced by PD98059 pretreatment. |
| CellLineName | MOCK |
|---|---|
| MedLine Reference | 14750214:5 |
| Sentence | A MEK1/2 inhibitor PD98059 induced transcription of both PPARgamma and SSAT genes in the activated Ki-ras clones, suggesting that the mitogen-activated protein kinases (MAPKs) were involved in the regulation of SSAT expression by PPARgamma. |