| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:121250-47-3:out-urn:agi-llid:5468::positive |
| Entities | PPARG <+-- CLA |
| References | 10 |
| Connectivity | 2 |
| Effect | positive |
| CellLineName | HT 29 |
|---|---|
| Journal | Gastr. Liver Phys |
| Journal Reference | v284 i6 pG996 (2003) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/284/6/G996 |
| MedLine Reference | 12571082:1285 |
| Sentence | CLA has been reported to be an activator of the peroxisome proliferator-activated receptor (PPAR)gamma ( 50 ). |
| Organism | Rattus norvegicus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 10985906:1 |
| Sentence | Conjugated linoleic acid (CLA) can activate PPARgamma in rat adipocytes, possibly explaining CLA's anti diabetic effects in Zucker fatty rats. |
| Organism | Mus musculus |
|---|---|
| Tissue | epithelia |
| MedLine Reference | 15362034:7 |
| Sentence | CLA induced PPAR gamma and delta, transcriptionally modulated PPAR gamma and delta-responsive gene clusters involved in lipid metabolism (uncoupling protein [UCP]1, UCP3, PPAR gamma coactivator 1alpha [PGC-1alpha], and CD36) and epithelial cell maturation (Gob-4 and Keratin 20). |
| Journal | Nutrition |
|---|---|
| Journal Reference | v133 i8 p2675 (2003) |
| Journal Link | http://www.nutrition.org/cgi/content/full/133/8/2675 |
| Organ | liver |
| MedLine Reference | 12888657:1200 |
| Sentence | CLA has been reported to be an activator of the peroxisome proliferator-activated receptor (PPAR)gamma ( 31 ). |
| Organism | Mus musculus |
|---|---|
| Journal | Reg.Int.Comp.Phys |
| Journal Reference | v276 i4 pR1172 (1999) |
| Tissue | islet |
| Journal Link | http://ajpregu.physiology.org/cgi/content/full/276/4/R1172 |
| Organ | pancreas |
| MedLine Reference | 10198400:1208 |
| Sentence | Therefore, CLA may decrease fatty acid levels by increasing fatty acid oxidation as well as influencing PPARgamma activation, resulting in improved insulin sensitivity. |
| Organism | Mus musculus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 12670481:4 |
| Sentence | T10c12 CLA and CNA also reduced protein levels of adipocyte transcription factors, peroxisome proliferator-activated receptor gamma and CCAAT/enhancer binding protein alpha. |
| Organism | Mus musculus |
|---|---|
| Tissue | muscle |
| MedLine Reference | 12468364:8 |
| Sentence | In pigs, prolonged dietary CLA treatment stimulated the expression of PPAR-gamma in the muscle. |
| Organ | thymal |
|---|---|
| MedLine Reference | 15671220:4 |
| Sentence | CLA enhanced the expression of interleukin-10 (IL-10) and peroxisome proliferator-activated receptor-gamma (PPARgamma) in spleen and thymus. |
| Journal | Nutrition |
|---|---|
| Journal Reference | v133 i10 p3041 (2003) |
| Journal Link | http://www.nutrition.org/cgi/content/full/133/10/3041 |
| MedLine Reference | 14519781:1201 |
| Sentence | In contrast, cis -9, trans -11 CLA increased the expression of PPARgamma and its downstream targets compared with vehicle controls. |
| Journal | Nutrition |
|---|---|
| CellType | t cell |
| Journal Reference | v133 i10 p3204 (2003) |
| Journal Link | http://www.nutrition.org/cgi/content/full/133/10/3204 |
| MedLine Reference | 14519812:1302 |
| Sentence | In examining the mechanism of T-cell immunoregulation, dietary CLA differentially modulated PPAR-alpha and PPAR-gamma expression in PCV2-infected pigs. |