| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:302-79-4:out-urn:agi-llid:5468::negative |
| Entities | PPARG |--- RA |
| References | 5 |
| Connectivity | 2 |
| Effect | negative |
| Organism | Mus musculus |
|---|---|
| Journal | J. Biol. Chem |
| CellType | adipocyte |
| Journal Reference | v272 i9 p5367 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/9/5367 |
| MedLine Reference | 9102400:1120 |
| Sentence | RA does not interfere with the induction of expression of C/EBPeta but blocks the expression of C/EBPalpha and PPARgamma and is able to repress expression of PPARgamma even after it is induced ( 41 ). |
| Organism | Mus musculus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 8657131:1 |
| Sentence | RA prevented induction of the adipogenic factors PPARgamma and C/EBPalpha. |
| Organism | Mus musculus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 9032283:3 |
| Sentence | In studies of normal preadipocytes, RA does not prevent C/EBPbeta induction but blocks induction of PPARgamma, C/EBPalpha, and adipogenesis. |
| Organism | Mus musculus |
|---|---|
| CellLineName | MCF7 |
| Journal | PNAS |
| Journal Reference | v95 i15 p8806 (1998) |
| Journal Link | http://www.pnas.org/cgi/content/full/95/15/8806 |
| MedLine Reference | 9671760:1165 |
| Sentence | The RAR-specific ligand, ATRA reversibly inhibited clonal growth of MCF7 cells and decreased the expression of PPARgamma and CD36 proteins. |
| MedLine Reference | 15583048:10 |
|---|---|
| Sentence | These results indicate that retinoic acid inhibits porcine preadipocyte differentiation by a mechanism that involves activation of the RAR and downregulation of PPARgamma, RXRalpha, and SREBP-1C mRNA. |