| Owner | Public |
|---|---|
| URN | urn:agi-Expression:inout-urn:agi-cas:50-02-2:out-urn:agi-llid:5468::positive |
| Entities | PPARG <+-- dexamethasone |
| References | 4 |
| Connectivity | 2 |
| Effect | positive |
| Organism | Mus musculus |
|---|---|
| CellLineName | C3H 10T1/2 |
| Tissue | mesenchyma |
| MedLine Reference | 10649448:6 |
| Sentence | Transfection studies in mouse mesenchymal C3H10T1/2 cells showed that it is the tandem repeat of the C/EBP binding site in PPARgamma2 promoter region that regulates dexamethasone-mediated PPARgamma2 gene activation. |
| Organism | Mus musculus |
|---|---|
| Journal | Lipid Res |
| CellType | macrophage |
| Journal Reference | v44 i10 p1877 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/10/1877 |
| MedLine Reference | 12867536:1200 |
| Sentence | In addition, dexamethasone and insulin also increased expression of phosphorylated PPARgamma, the inactive form of PPARgamma ( Fig. 9A ) . |
| Organism | Mus musculus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 8754811:1 |
| Sentence | In this report, we demonstrate that peroxisome proliferator-activated receptor gamma (PPARgamma) expression in 3T3-L1 preadipocytes is induced by MIX and DEX, suggesting that C/EBPbeta and C/EBPdelta may be involved in this process. |
| Organism | Rattus norvegicus |
|---|---|
| CellType | adipocyte |
| MedLine Reference | 12753899:9 |
| Sentence | These results indicate that dexamethasone reverses the TGF-beta-mediated suppression of adipocyte differentiation by regulating the expression of C/EBPalpha and PPARgamma, which is dependent on the cellular context. |