| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:5468:out-urn:agi-cas:67254-79-9::unknown |
| Entities | PPARG ---> fatty acid |
| References | 9 |
| Connectivity | 2 |
| Effect | unknown |
| Tissue | islet |
|---|---|
| Organ | pancreas |
| MedLine Reference | 14625208:1041 |
| Sentence | Because PPARgamma is thought to stimulate fatty acid uptake and their intracellular binding and esterification ( 24 , 37 ), a role of these nuclear receptors in mediating the FFA effects on insulin secretion was postulated. |
| Journal | Endocrin. Metabol |
| Journal Reference | v286 i4 pE560 (2004) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/286/4/E560 |
| Tissue | fat |
|---|---|
| Organism | Rattus norvegicus |
| MedLine Reference | 11181544:1200 |
| Sentence | Strikingly, expression of these same genes was increased in adipose tissue in response to GW1929, suggesting that PPARgamma activation promotes a flux of fatty acids into adipose tissue and away from muscle (Fig. 3 ). |
| Journal | Endocrinology |
| Journal Reference | v142 i3 p1269 (2001) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/142/3/1269 |
| Tissue | fat |
|---|---|
| Organism | Rattus norvegicus |
| MedLine Reference | 15059948:1163 |
| Sentence | It is likely that this increase in NEFA clearance is the functional result of the well-described effects of PPARgamma agonists to stimulate the transcription of genes involved in NEFA transport and storage in WAT ( 25 ). |
| Journal | Endocrinology |
| Journal Reference | v145 i7 p3158 (2004) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/7/3158 |
| Tissue | fat |
|---|---|
| Organism | Mus musculus |
| MedLine Reference | 12200443:1101 |
| Sentence | Induction of insulin-stimulated glucose uptake and fatty acid uptake by PPAR gamma isoforms. |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i44 p41925 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/44/41925 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 9353271:1216 |
| CellType | adipocyte |
| Sentence | The increase in FATP and ACS expression in differentiated adipocyte-like cells caused by PPARgamma ligands will result in an increased delivery of fatty acids to the adipocytes, which possibly sustains a positive regulatory feedback loop involving continued PPARgamma activation of the FATP and ACS ( 28 ) genes and aimed at promoting and maintaining the mature adipocyte phenotype. |
| Journal | J. Biol. Chem |
| Journal Reference | v272 i45 p28210 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/45/28210 |
| Tissue | fat |
|---|---|
| MedLine Reference | 9694545:3 |
| Sentence | Activation of PPARgamma will selectively induce the expression of several genes involved in fatty acid uptake, such as lipoprotein lipase, fatty acid transport protein and acyl-CoA synthetase, in adipose tissue without changing their expression in muscle tissue. |
| Organ | placenta |
|---|---|
| MedLine Reference | 15573522:7 |
| CellType | trophoblast |
| Sentence | In fact, involvement of several nuclear transcription factors (PPARgamma, LXR, RXR, and SREBP-1) is critical in the expression of genes responsible for fatty acids uptake, placental trophoblast differentiation and hCG production. |
| Tissue | fat |
|---|---|
| Organism | Rattus norvegicus |
| MedLine Reference | 11160850:1247 |
| Sentence | PPARgamma agonists induce a preferential delivery of fatty acids to adipose tissue via the induction of LPL and enzymes and transport proteins that facilitate fatty acid uptake into adipose tissue (Schoonjans et al., 1996 ). |
| Journal | Mol. Pharm |
| Journal Reference | v59 i2 p170 (2001) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/59/2/170 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 9843961:1172 |
| CellType | adipocyte |
| Sentence | Although the gene products regulated by PPARgamma participate in fatty acid uptake and metabolism in the adipocyte, it remains uncertain whether changes in expression of these genes underlie the insulin-sensitizing effects of TZDs. |
| Journal | PNAS |
| Journal Reference | v95 i25 p14751 (1998) |
| Journal Link | http://www.pnas.org/cgi/content/full/95/25/14751 |