| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:5468:out-urn:agi-cas:57-88-5::unknown |
| Entities | cholesterol <--- PPARG |
| References | 11 |
| Connectivity | 2 |
| Effect | unknown |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 14615393:1208 |
| CellType | macrophage |
| Sentence | The remaining question here is the balance between the production of free cholesterol by LAL that potentially could be toxic and a cause of macrophage cell death and the production of free fatty acid by LAL that could be a ligand for PPARgamma to activate the cholesterol efflux through LXRalpha and ABCAI pathway and anti-inflammatory activity of PPARgamma. |
| Journal | ATVB |
| Journal Reference | v24 i1 p147 (2004) |
| Journal Link | http://atvb.ahajournals.org/cgi/content/full/24/1/147 |
| MedLine Reference | 3391210229 |
|---|---|
| CellType | macrophage |
| Sentence | In macrophages and perhaps other tissues, expression of PPARgamma, a target of known prescription drugs, establishes an additional layer of regulation of cholesterol efflux and absorption while RXR participates at all sites as a partner of PPARgamma, LXR alpha/eta, and FXR. |
| Journal | Cell |
| Journal Reference | v103 i1 p1 (2000) |
| Journal Link | http://www.cell.com/cgi/content/full/103/1/1 |
| MedLine Reference | 12746275:1100 |
|---|---|
| CellType | macrophage |
| Sentence | However, a follow-up study demonstrated that PPARgamma also promotes cholesterol efflux through the induction of a transcriptional cascade involving the nuclear sterol receptor LXRalpha and its downstream target ABCA1, a membrane transporter that is important for HDL-mediated reverse cholesterol transport ( 51 , 52 , 53 , 54 ). |
| Journal | Endocrinology |
| Journal Reference | v144 i6 p2201 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/6/2201 |
| MedLine Reference | 11459852:1119 |
|---|---|
| Sentence | PPARgamma also induces the expression of proteins involved in reverse cholesterol transport, presumably leading to a net reduction of cholesterol in atherosclerotic lesions. |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i41 p37731 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/41/37731 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12193599:1202 |
| CellType | macrophage |
| Sentence | Interestingly, agonists of PPARgamma increase reverse cholesterol transport in isolated macrophages ( 10 , 37 ) and decrease atherosclerosis in rodent models ( 38 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i43 p40722 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/43/40722 |
| MedLine Reference | 11135616:7 |
|---|---|
| CellType | macrophage |
| Sentence | Moreover, PPAR-alpha and PPAR-gamma activators increase apoAI-induced cholesterol efflux from normal macrophages. |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11172721:1 |
| CellType | macrophage |
| Sentence | We provide evidence here that in addition to lipid uptake, PPAR gamma regulates a pathway of cholesterol efflux. |
| MedLine Reference | 10409739:1104 |
|---|---|
| Sentence | In both cell lines, PPARgamma protein was induced at least ninefold upon cholesterol depletion during 24 h, a condition known to enhance the production of mature and active ADD-1/SREBP-1 ( 31 , 50 ) (Fig. 2 C). |
| Journal | Mol. Cell. Biol |
| Journal Reference | v19 i8 p5495 (1999) |
| Journal Link | http://mcb.asm.org/cgi/content/full/19/8/5495 |
| CellLineName | 3T3 L1 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11604492:1040 |
| CellType | macrophage |
| Sentence | As a consequence of this regulation, ligands for LXR and PPARgamma additively promote cholesterol efflux from macrophages. |
| Journal | Mol. Cell. Biol |
| Journal Reference | v21 i22 p7558 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/22/7558 |
| MedLine Reference | 15087471:1242 |
|---|---|
| Sentence | Thus, the beneficial effects of PPARgamma ligands seen in atherosclerosis in mice and humans can be attributed to both increased cholesterol efflux and reduced inflammation ( 85 , 89 , 90 , 91 , 92 , 93 , 94 ). |
| Journal | Mol. Endocrin |
| Journal Reference | v18 i6 p1321 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/6/1321 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12540828:1020 |
| CellType | macrophage |
| Journal | PNAS |
| Journal Reference | v100 i3 p1268 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/3/1268 |