| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:5468:out-urn:agi-smol:1808964::unknown |
| Entities | lipids <--- PPARG |
| References | 7 |
| Connectivity | 2 |
| Effect | unknown |
| MedLine Reference | 12746275:1033 |
|---|---|
| CellType | macrophage |
| Sentence | PPARgamma plays an important role in the balance between lipid influx and efflux, whereas PPARdelta is the major sensor for VLDL in the mouse macrophage. |
| Journal | Endocrinology |
| Journal Reference | v144 i6 p2201 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/6/2201 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 15131020:1019 |
| CellType | adipocyte |
| Sentence | PPARgamma activation also enhances the expression of genes that favor lipid uptake and retention and decreases the expression of genes that lower adipocyte lipid content ( 3 , 4 , 5 ). |
| Journal | Endocrinology |
| Journal Reference | v145 i8 p3925 (2004) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/8/3925 |
| Organism | Mus musculus |
|---|---|
| Organ | liver |
| MedLine Reference | 12805374:1165 |
| CellType | hepatocyte |
| Sentence | The levels of both ADRP and aP2 mRNA were reduced in the AZIP LKO mice, suggesting that liver PPARgamma also contributes to regulation of lipid transport and storage within the hepatocytes. |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i36 p34268 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/36/34268 |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 15007093:1202 |
| CellType | macrophage |
| Sentence | LPA activates CD36-mediated lipid uptake into macrophages through a PPARgamma-PPREA?dependent mechanism ( 11 ). |
| Journal | J. Exp. Med |
| Journal Reference | v199 i6 p763 (2004) |
| Journal Link | http://www.jem.org/cgi/content/full/199/6/763 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12970571:1 |
| CellType | macrophage |
| Sentence | The peroxisome proliferator-activated receptor (PPAR) gamma promotes lipid uptake and efflux in these atherogenic cells. |
| Organ | placenta |
|---|---|
| MedLine Reference | 14671211:2 |
| CellType | adipocyte |
| Sentence | The nuclear receptor peroxisome proliferator-activated receptor-gamma (PPARgamma) stimulates lipid uptake by adipocytes and enhances differentiation of placental trophoblasts. |
| Tissue | fat |
|---|---|
| Organism | Mus musculus |
| MedLine Reference | 14660788:1179 |
| Sentence | PPARgamma regulates a number of genes involved in lipid uptake and storage in adipose tissue. |
| Journal | PNAS |
| Journal Reference | v100 i26 p15712 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/26/15712 |