| Transport Type | unknown |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:5468:out-urn:agi-cas:50-99-7::unknown |
| Entities | glucose <--- PPARG |
| References | 10 |
| Connectivity | 2 |
| Effect | unknown |
| Tissue | fat |
|---|---|
| MedLine Reference | 2710514603 |
| Sentence | The discovery that the gene encoding the signaling protein CAP (see above) is upregulated by PPARgamma in mature fat cells, both in vitro and in vivo , suggests a mechanism for increased insulin-stimulated glucose uptake by PPARgamma activators (Ribon et al., 1998 ). |
| Journal | Cell |
| Journal Reference | v104 i4 p517 (2001) |
| Journal Link | http://www.cell.com/cgi/content/full/104/4/517 |
| MedLine Reference | 12540598:1276 |
|---|---|
| CellType | adipocyte |
| Sentence | J Clin Endocrinol Metab 87 :2784 A?A?A?2791,2002 [Abstract/ Free Full Text] Nugent C, Prins JB, Whitehead JP, Savage D, Wentworth JM, Chatterjee VK, OA?A?A?Rahilly S: Potentiation of glucose uptake in 3T3-L1 adipocytes by PPAR gamma agonists is maintained in cells expressing a PPAR gamma dominant-negative mutant: evidence for selectivity in the downstream responses to PPAR gamma activation. |
| Journal | Diabetes |
| Journal Reference | v52 i2 p283 (2003) |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/52/2/283 |
| CellLineName | 3T3 L1 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 10075691:1008 |
| CellType | fibroblast |
| Sentence | Reconstitution of Insulin-sensitive Glucose Transport in Fibroblasts Requires Expression of Both PPARgamma and C/EBPalpha * Amr K. |
| Journal | J. Biol. Chem |
| Journal Reference | v274 i12 p7946 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/12/7946 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11124961:1022 |
| CellType | adipocyte |
| Sentence | Furthermore, adenoviral expression of a dominant-negative PPARgamma mutant attenuated the AA potentiation of basal glucose uptake. |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i12 p9149 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/12/9149 |
| CellLineName | 3T3 L1 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12097321:1245 |
| CellType | fibroblast |
| Sentence | For example, El-Jack and colleagues ( 40 ) found that reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha. |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i37 p34322 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/37/34322 |
| Organism | Rattus norvegicus |
|---|---|
| Organ | brain |
| MedLine Reference | 12486128:1014 |
| Sentence | In many cells, PPARgamma agonists increase glucose uptake and metabolism. |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i8 p5828 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/8/5828 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 11579205:1 |
| Sentence | The precise mechanisms whereby activation of PPAR gamma leads to increased glucose uptake in metabolically active cells remain to be determined. |
| Tissue | muscle |
|---|---|
| Organism | Mus musculus |
| MedLine Reference | 14525954:12 |
| Sentence | In contrast, rosiglitazone-mediated activation of PPARgamma induces gene expression associated with glucose uptake, fatty acid synthesis, and lipid storage. |
| Tissue | blood |
|---|---|
| MedLine Reference | 15828220:4 |
| CellType | adipocyte |
| Sentence | PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. |
| MedLine Reference | 11110884:1272 |
|---|---|
| CellType | fibroblast |
| Sentence | Reconstitution of insulin-sensitive glucose transport in fibroblasts requires expression of both PPARgamma and C/EBPalpha. |
| Journal | Nutrition |
| Journal Reference | v130 i12 p3116S (2000) |
| Journal Link | http://www.nutrition.org/cgi/content/full/130/12/3116S |