| Transport Type | import |
|---|---|
| Owner | Public |
| URN | urn:agi-MolTransport:inout-urn:agi-llid:5468:out-urn:agi-go:0005322::positive |
| Entities | PPARG --+> LDL |
| References | 10 |
| Connectivity | 2 |
| Effect | positive |
| MedLine Reference | 12623786:1290 |
|---|---|
| CellType | macrophage |
| Sentence | PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. |
| Journal | Heart Circul |
| Journal Reference | v285 i1 pH38 (2003) |
| Journal Link | http://ajpheart.physiology.org/cgi/content/full/285/1/H38 |
| Organism | Rattus norvegicus |
|---|---|
| MedLine Reference | 10930400:1033 |
| CellType | macrophage |
| Sentence | In monocytes/macrophages, PPARgamma activators suppress production of inflammatory cytokines ( 18 ) and stimulate the expression of scavenger receptors and the uptake of oxidized low density lipoprotein, leading to differentiation of monocytes/macrophages to foam cells ( 19 ). |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i42 p33142 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/42/33142 |
| MedLine Reference | 10588940:1865 |
|---|---|
| CellType | macrophage |
| Sentence | PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. |
| Journal | Lipid Res |
| Journal Reference | v40 i12 p2143 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/12/2143 |
| MedLine Reference | 10588946:1233 |
|---|---|
| CellType | macrophage |
| Sentence | PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. |
| Journal | Lipid Res |
| Journal Reference | v40 i12 p2204 (1999) |
| Journal Link | http://www.jlr.org/cgi/content/full/40/12/2204 |
| MedLine Reference | 11861659:1493 |
|---|---|
| CellType | macrophage |
| Sentence | PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. |
| Journal | Lipid Res |
| Journal Reference | v43 i2 p177 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/2/177 |
| MedLine Reference | 11907138:1400 |
|---|---|
| CellType | macrophage |
| Sentence | PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. |
| Journal | Lipid Res |
| Journal Reference | v43 i4 p557 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/4/557 |
| MedLine Reference | 12700342:1564 |
|---|---|
| CellType | macrophage |
| Sentence | PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. |
| Journal | Lipid Res |
| Journal Reference | v44 i6 p1224 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/6/1224 |
| Organism | Mus musculus |
|---|---|
| MedLine Reference | 12754280:1699 |
| CellType | macrophage |
| Sentence | PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. |
| Journal | Lipid Res |
| Journal Reference | v44 i8 p1441 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/8/1441 |
| Tissue | fat |
|---|---|
| MedLine Reference | 12601635:0 |
| CellType | adipocyte |
| Sentence | Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) is a key component in adipocyte differentiation and fat-specific gene expression and may modulate macrophage functions, like proinflammatory activities, and stimulate oxidized low-density lipoprotein (ox-LDL) uptake. |
| Tissue | intima |
|---|---|
| Organ | artery |
| MedLine Reference | 15087471:1237 |
| CellType | macrophage |
| Sentence | A proatherogenic property of PPARgamma is revealed by the stimulation of expression of the scavenger receptor CD36 by activated PPARgamma, which further promotes oxidized LDL uptake and foam cell formation ( 81 , 82 ). |
| Journal | Mol. Endocrin |
| Journal Reference | v18 i6 p1321 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/6/1321 |