| Entities | PPARG ---- SLC2A4 |
|---|---|
| References | 10 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:6517:inout-urn:agi-llid:5468::unknown |
| CellType | adipocyte |
|---|---|
| CellLineName | CHO-K1 |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i33 p30614 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/33/30614 |
| MedLine Reference | 12777391:1142 |
| Sentence | Effects of TZD on GLUT4 Promoter Regulation by PPARgamma1 and PPARgamma2 Because TZDs enhance insulin sensitivity, it has been assumed that PPARgamma (and its ligands) enhances insulin sensitivity by ensuring proper expression levels of key glucoregulatory genes. |
| Organism | Mus musculus |
| Journal | Cancer Res |
|---|---|
| Journal Reference | v64 i7 p2627 (2004) |
| Journal Link | http://cancerres.aacrjournals.org/cgi/content/full/64/7/2627 |
| MedLine Reference | 15059920:1209 |
| Sentence | Additionally, we recently showed that the PPARgamma nuclear receptor also inhibits the transcriptional activity of GLUT4 promoter (28) . |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| CellLineName | NIH 3T3 |
| Journal | Cell Sci |
| Journal Reference | v115 i18 p3601 (1997) |
| Journal Link | http://jcs.biologists.org/cgi/content/full/115/18/3601 |
| MedLine Reference | 12186946:1123 |
| Sentence | While it is not clear whether PPARgamma or which C/EBP is involved in the insulin-stimulated glucose uptake in mature adipocytes, it has been demonstrated in the study using A?A?/delta39 NIH-3T3 fibroblasts expressing C/EBPA?A? and C/EBPdelta but not C/EBPalpha, that the enhanced expression and activation of PPARgamma stimulate synthesis of GLUT4 protein and insulin-responsive glucose uptake (Wu et al., 1998 ). |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i41 p37731 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/41/37731 |
| MedLine Reference | 11459852:1100 |
| Sentence | PPARgamma activation in fat increases levels of Glut4, the insulin-stimulated glucose transporter ( 44 ), and may have other direct effects on important genes involved in glucose homeostasis. |
| CellType | adipocyte |
|---|---|
| CellLineName | 3T3 |
| Journal | Lipid Res |
| Journal Reference | v44 i7 p1287 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/7/1287 |
| MedLine Reference | 12730300:1714 |
| Sentence | PPARgamma induces the insulin-dependent glucose transporter GLUT4 in the absence of C/EBPalpha during the conversion of 3T3 fibroblasts into adipocytes. |
| Organism | Mus musculus |
| Tissue | epididymal |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i48 p48283 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/48/48283 |
| MedLine Reference | 12970362:1237 |
| Sentence | Still, the PPARgamma activator is able to regulate GLUT4 expression in the absence of LXRs, suggesting that ablation of the LXRs results in an altered phenotype with disruption of a mechanism that normally prevents PPARgamma activation of the GLUT4 promoter in mice with normal insulin levels. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Endocrin. Metabol |
| Journal Reference | v279 i2 pE386 (2000) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/279/2/E386 |
| MedLine Reference | 10913039:1191 |
| Sentence | At the final stage of differentiation, expression of adipogenic genes such as LPL, aP2, or GLUT-4 is induced by PPARgamma alone or cooperatively with C/EBPalpha, which results in mature adipocyte phenotype ( 32 ). |
| Organism | Mus musculus |
| CellType | monocyte |
|---|---|
| MedLine Reference | 9808320:7 |
| Sentence | These results indicate that the mechanism by which YM268 increased glucose uptake, may be accounted for in part by the enhancement of GLUT1 and GLUT4 expression through PPARgamma activation. |
| Organism | Mus musculus |
| CellType | fibroblast |
|---|---|
| MedLine Reference | 9421462:3 |
| Sentence | In addition, enhanced expression of a ligand-activated form of PPARgamma in the beta/delta39 fibroblasts stimulates synthesis of GLUT4 protein and gives rise to a population of adipocytic cells that take up glucose in direct response to insulin. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i37 p34322 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/37/34322 |
| MedLine Reference | 12097321:1242 |
| Sentence | PPARgamma is also essential for GLUT4 expression ( 22 , 43 ). |
| Organism | Mus musculus |