| Entities | RETN ---- PPARG |
|---|---|
| References | 9 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:56729:inout-urn:agi-llid:5468::unknown |
| Tissue | testis |
|---|---|
| Journal | Cell Sci |
| Journal Reference | v117 i15 p3247 (2004) |
| Journal Link | http://jcs.biologists.org/cgi/content/full/117/15/3247 |
| MedLine Reference | 15226398:1254 |
| Sentence | In our experiments, testicular levels of resistin mRNA were inhibited by exposure to rosiglitazone, both in vivo and in vitro, suggesting the involvement of testicular PPARgamma in local control of resistin gene expression. |
| Organism | Mus musculus |
| CellLineName | GS |
|---|---|
| Tissue | fat |
| Journal | Diabetes |
| Journal Reference | v52 i7 p1611 (2003) |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/52/7/1611 |
| MedLine Reference | 12829623:1248 |
| Sentence | Nature 409 :307 A?A?A?312,2001 [Medline] Way JM, Gorgun CZ, Tong Q, Uysal KT, Brown KK, Harrington WW, Oliver WR Jr, Willson TM, Kliewer SA, Hotamisligil GS: Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. |
| CellType | adipocyte |
|---|---|
| CellLineName | 3T3 L1 |
| Tissue | fat |
| Journal | Endocrin. Metabol |
| Journal Reference | v285 i1 pE106 (2003) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/285/1/E106 |
| MedLine Reference | 12618360:1024 |
| Sentence | These studies suggested that suppression of resistin expression by PPARgamma agonists (TZDs) might explain the beneficial effects of these compounds in insulin-resistant states. |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i28 p25651 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/28/25651 |
| MedLine Reference | 11373275:1010 |
| Sentence | All Versions of this Article: 276/28/25651 (most recent) C100189200v1 ACCELERATED PUBLICATION Adipose Tissue Resistin Expression Is Severely Suppressed in Obesity and Stimulated by Peroxisome Proliferator-activated Receptor gamma Agonists * James M. |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i22 p19754 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/22/19754 |
| MedLine Reference | 11901161:1023 |
| Sentence | Other TZD- and non-TZD PPARgamma ligands also down-regulated resistin expression. |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v43 i2 p177 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/2/177 |
| MedLine Reference | 11861659:1426 |
| Sentence | Adipose tissue resistin expression is severely suppressed in obesity and stimulated by peroxisome proliferator-activated receptor gamma agonists. |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 11574398:1 |
| Sentence | Furthermore, peroxisome proliferator-activated receptor-gamma (PPAR-gamma) agonists appear to inhibit resistin expression in murine adipocytes, providing a possible explanation for the mode of action of this class of insulin sensitizers (2). |
| Tissue | fat |
|---|---|
| MedLine Reference | 12235730:5 |
| Sentence | The new class of thiazolidinediones (glitazones), binding to the peroxisome proliferator activated receptor (PPAR-gamma) lowers the levels of resistin and increases adiponectin, resulting in an improvement of glucose homeostasis. |
| CellType | myocyte |
|---|---|
| CellLineName | L6 |
| MedLine Reference | 12437985:4 |
| Sentence | Overexpression of PPARgamma markedly reduced resistin expression, whereas PPARalpha had no significant effect. |
| Organism | Mus musculus |