| Entities | PPARG ---- Cd36 |
|---|---|
| References | 43 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:948:inout-urn:agi-llid:5468::unknown |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i41 p37731 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/41/37731 |
| MedLine Reference | 11459852:1122 |
| Sentence | Interestingly, recent genetic studies show that PPARgamma is not required for the formation of macrophages from monocytes, although macrophages lacking PPARgamma have greatly reduced basal expression of CD36 ( 62 , 63 ). |
| CellType | macrophage |
|---|---|
| CellLineName | HepG 2 |
| Tissue | fat |
| Journal | J. Biol. Chem |
| Journal Reference | v277 i18 p15703 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/18/15703 |
| MedLine Reference | 11867619:1189 |
| Sentence | Both PPARalpha and PPARgamma Ligands Induce FAT/CD36 mRNA from the Distal Promoter of the Human Gene in THP-1 but Not in HepG2 Cells-- It has been established that the human FAT/CD36 mRNA is induced by PPARgamma ligands in monocyte-macrophages ( 30 ). |
| Organism | Mus musculus |
| Tissue | endothelial |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i37 p34176 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/37/34176 |
| MedLine Reference | 12107164:1171 |
| Sentence | Thus, as expected, the constitutively active PPAR-gamma induced the gene expression of CD36, which has a consensus PPRE in its promoter and is considered to be a PPAR-gamma-specific target gene ( 20 ). |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i36 p34268 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/36/34268 |
| MedLine Reference | 12805374:1158 |
| Sentence | Ablation of liver PPARgamma reduced CD36 mRNA levels by only 16 and 39% in the AZIP and WT mice, respectively. |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i12 p11570 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/12/11570 |
| MedLine Reference | 14688261:1384 |
| Sentence | The 12/15-LOX-derived metabolites then act as endogenous ligands of PPARgamma to mediate transcriptional induction of the CD36 gene in these cells. |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i10 p1877 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/10/1877 |
| MedLine Reference | 12867536:1040 |
| Sentence | CD36 expression is up-regulated by PPARgamma during the differentiation of both types of cells ( 18 , 21 ). aP2 is also expressed by both adipocytes and macrophages. |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| MedLine Reference | 11135614:2 |
| Sentence | PPAR-gamma is required for basal expression of CD36, but not for expression of the other major scavenger receptor responsible for uptake of modified lipoproteins, SR-A. |
| Organism | Mus musculus |
| Tissue | intima |
|---|---|
| MedLine Reference | 12169646:3 |
| Sentence | The PPARgamma ligand rosiglitazone more potently induced CD36 expression at low concentrations, and cell death by apoptosis at higher concentrations in intimal compared with medial smooth muscle cells. |
| Organism | Rattus norvegicus |
| CellLineName | J774 |
|---|---|
| MedLine Reference | 12193207:4 |
| Sentence | Using pharmaceutical inhibitors and dominant active MAP kinase kinases, we demonstrated that activation of the p38 pathway, but not the ERK or JNK pathways, is necessary and sufficient to transactivate PPARgamma, a nuclear receptor that has recently been shown to play a pivotal role in oxLDL-induced CD36 expression. |
| Organism | Mus musculus |
| CellType | monocyte |
|---|---|
| MedLine Reference | 12528124:8 |
| Sentence | The induced PPAR gamma was functional, since a PPAR gamma ligand was able to up-regulate CD36 expression on monocytes. |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| MedLine Reference | 12942148:7 |
| CellType | macrophage |
|---|---|
| MedLine Reference | 14752028:5 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| MedLine Reference | 15769457:1 |
| CellType | macrophage |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v21 i22 p7558 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/22/7558 |
| MedLine Reference | 11604492:1252 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Tissue | intima |
| Organ | artery |
| Journal | Mol. Endocrin |
| Journal Reference | v18 i6 p1321 (2004) |
| Journal Link | http://mend.endojournals.org/cgi/content/full/18/6/1321 |
| MedLine Reference | 15087471:1237 |
| Journal | PNAS |
|---|---|
| Journal Reference | v100 i1 p131 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/1/131 |
| MedLine Reference | 12502787:1137 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| CellLineName | 3T3F442A |
| Journal | Cell |
| Journal Reference | v93 i2 p241 (1998) |
| Journal Link | http://www.cell.com/cgi/content/full/93/2/241 |
| MedLine Reference | 3727197776 |
| CellLineName | HeLa |
|---|---|
| Journal | Cell |
| Journal Reference | v93 i2 p229 (1998) |
| Journal Link | http://www.cell.com/cgi/content/full/93/2/229 |
| MedLine Reference | 4225185349 |
| CellType | adipocyte |
|---|---|
| Organ | liver |
| Journal | Endocrin. Metabol |
| Journal Reference | v286 i2 pE168 (2004) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/286/2/E168 |
| MedLine Reference | 14519597:1174 |
| CellLineName | THP I |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i2 p1241 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/2/1241 |
| MedLine Reference | 10625669:1107 |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i49 p45888 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/49/45888 |
| MedLine Reference | 11590167:1242 |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v42 i4 p521 (2001) |
| Journal Link | http://www.jlr.org/cgi/content/full/42/4/521 |
| MedLine Reference | 11290823:1522 |
| Organism | Mus musculus |
| Journal | Lipid Res |
|---|---|
| Journal Reference | v43 i11 p1818 (2002) |
| Journal Link | http://www.jlr.org/cgi/content/full/43/11/1818 |
| MedLine Reference | 12401880:1821 |
| CellType | macrophage |
|---|---|
| MedLine Reference | 11595817:3 |
| CellType | macrophage |
|---|---|
| MedLine Reference | 10432118:4 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| MedLine Reference | 14970117:10 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| MedLine Reference | 15701701:6 |
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Journal | Cell |
| Journal Reference | v93 i2 p229 (1998) |
| Journal Link | http://www.cell.com/cgi/content/full/93/2/229 |
| MedLine Reference | 3505936870 |
| CellLineName | THP I |
|---|---|
| Journal | Cell |
| Journal Reference | v93 i2 p241 (1998) |
| Journal Link | http://www.cell.com/cgi/content/full/93/2/241 |
| MedLine Reference | 2516161613 |
| CellType | monocyte |
|---|---|
| Journal | Cell |
| Journal Reference | v93 i2 p153 (1998) |
| Journal Link | http://www.cell.com/cgi/content/full/93/2/153 |
| MedLine Reference | 2874105539 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v276 i19 p16015 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/19/16015 |
| MedLine Reference | 11279149:1051 |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i47 p44258 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/47/44258 |
| MedLine Reference | 11557774:1040 |
| CellType | macrophage |
|---|---|
| MedLine Reference | 10680041:6 |
| MedLine Reference | 10865832:5 |
|---|---|
| Organism | Mus musculus |
| CellType | macrophage |
|---|---|
| Tissue | alveola |
| Journal | AJRCMB |
| Journal Reference | v29 i6 p677 (2003) |
| Journal Link | http://ajrcmb.atsjournals.org/cgi/content/full/29/6/677 |
| MedLine Reference | 12805087:1120 |
| CellType | monocyte |
|---|---|
| CellLineName | THP I |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i48 p49747 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/48/49747 |
| MedLine Reference | 15375153:1029 |
| Tissue | intima |
|---|---|
| Journal | J. Exp. Med |
| Journal Reference | v199 i6 p763 (2004) |
| Journal Link | http://www.jem.org/cgi/content/full/199/6/763 |
| MedLine Reference | 15007093:1198 |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i11 p8755 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/11/8755 |
| MedLine Reference | 11748246:1141 |
| CellType | monocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i15 p13029 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/15/13029 |
| MedLine Reference | 11809750:1125 |
| CellType | macrophage |
|---|---|
| Journal | PNAS |
| Journal Reference | v98 i2 p507 (2001) |
| Journal Link | http://www.pnas.org/cgi/content/full/98/2/507 |
| MedLine Reference | 11149950:1170 |
| Organism | Mus musculus |
| Organ | aorta |
|---|---|
| Journal | Cell |
| Journal Reference | v93 i2 p241 (1998) |
| Journal Link | http://www.cell.com/cgi/content/full/93/2/241 |
| MedLine Reference | 3829271400 |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i5 p3195 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/5/3195 |
| MedLine Reference | 11035013:1210 |
| Organism | Mus musculus |
| MedLine Reference | 15104237:0 |
|---|