| Entities | PPARG ---- CEBPD |
|---|---|
| References | 37 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5468:inout-urn:agi-llid:1052::positive |
| CellType | adipocyte |
|---|---|
| Journal | Cell Sci |
| Journal Reference | v117 i16 p3605 (2004) |
| Journal Link | http://jcs.biologists.org/cgi/content/full/117/16/3605 |
| MedLine Reference | 15252128:1171 |
| Sentence | These results, taken together, suggest that the coordinated expression of C/EBPA? and C/EBPdelta is a prerequisite for the efficient expression of PPARgamma, leading to fully differentiated adipocytes. |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i21 p18464 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/21/18464 |
| MedLine Reference | 11279134:1241 |
| Sentence | In this model, C/EBPeta and C/EBPdelta regulate production of PPARgamma ligands as well as PPARgamma2 and C/EBPalpha expression. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i51 p49776 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/51/49776 |
| MedLine Reference | 12351639:1157 |
| Sentence | Second, calcineurin may inhibit adipocyte differentiation by affecting a parallel pathway to C/EBPeta and C/EBPdelta that is also required for the efficient expression of PPARgamma and C/EBPalpha. |
| Organism | Mus musculus |
| CellLineName | NIH 3T3 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i11 p9609 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/11/9609 |
| MedLine Reference | 12524424:1139 |
| Sentence | NIH3T3 cells expressing C/EBPdelta had lower levels of PPARgamma, aP2, and adipsin than C/EBPbeta-expressing cells, consistent with the lower number of lipid-filled cells in cultures expressing C/EBPdelta versus C/EBPbeta (Fig. 1 B ). |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Organ | liver |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i39 p37672 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/39/37672 |
| MedLine Reference | 12821652:1207 |
| Sentence | C/EBPbeta and C/EBPdelta induce the expression of PPARgamma ( 9 , 10 ) via two C/EBP binding sites in the promoter of PPARgamma2 ( 38 , 47 ). |
| Organism | Rattus norvegicus |
| CellLineName | 3T3 L1 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i21 p21740 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/21/21740 |
| MedLine Reference | 15024020:1184 |
| Sentence | Both C/EBPbeta and C/EBPdelta are essential in eliciting the expression of PPARgamma, which in turn leads to the induction of the expression of C/EBPalpha ( 10 , 37 , 38 ). |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i32 p29625 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/32/29625 |
| MedLine Reference | 11418611:1086 |
| Sentence | INTRODUCTION EXPERIMENTAL PROCEDURES RESULTS DISCUSSION REFERENCES During the adipocyte differentiation, C/EBPeta and C/EBPdelta were expressed at a relatively early stage and induced the PPARgamma as well as the C/EBPalpha gene ( 8 , 9 , 13 , 20 ). |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i10 p1877 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/10/1877 |
| MedLine Reference | 12867536:1027 |
| Sentence | In confluent preadipocytes, CCAAT/enhancer binding protein (C/EBP)A? and C/EBPdelta are induced primarily by dexamethasone and form a C/EBPA?/delta heterodimer, leading to peroxisome proliferator-activated receptor (PPAR)gamma and C/EBPalpha activation. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| CellLineName | 3T3 L1 |
| Journal | Cell |
| Journal Reference | v99 i3 p239 (1999) |
| Journal Link | http://www.cell.com/cgi/content/full/99/3/239 |
| MedLine Reference | 3016779952 |
| Sentence | These studies provided important insight into the existence of cascades (C/EBPeta and C/EBPdelta inducing PPARgamma expression), positive cross-regulation loops (PPARgamma inducing C/EBPalpha expression and vice versa), and possibly autoregulatory loops (C/EBPalpha and PPARgamma inducing their own expression) that all promote and maintain the differentiated state. |
| CellType | adipocyte |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v16 i1 p22 (2002) |
| Journal Link | http://www.genesdev.org/cgi/content/full/16/1/22 |
| MedLine Reference | 11782441:1022 |
| Sentence | In the present model of the transcriptional cascade leading to adipogenesis, C/EBPeta and C/EBPdelta induce low levels of PPARgamma and C/EBPalpha, which are then able to induce each other's expression in a positive feedback loop that promotes and maintains the differentiated state. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v17 i11 p1352 (2003) |
| Journal Link | http://www.genesdev.org/cgi/content/full/17/11/1352 |
| MedLine Reference | 12782654:1214 |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v18 i16 p1970 (2004) |
| Journal Link | http://www.genesdev.org/cgi/content/full/18/16/1970 |
| MedLine Reference | 15289464:1019 |
| Organism | Mus musculus |
| CellType | fibroblast |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i33 p34840 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/33/34840 |
| MedLine Reference | 15184384:1278 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v272 i47 p29729 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/47/29729 |
| MedLine Reference | 9368042:1034 |
| Organism | Mus musculus |
| CellLineName | UMR 106 |
|---|---|
| MedLine Reference | 9367890:2 |
| Organism | Mus musculus |
| CellType | fibroblast |
|---|---|
| CellLineName | NIH 3T3 |
| MedLine Reference | 9421462:2 |
| Organism | Mus musculus |
| MedLine Reference | 12215492:2 |
|---|---|
| Organism | Rattus norvegicus |
| Journal | Mol. Cell. Biol |
|---|---|
| Journal Reference | v24 i22 p9863 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/22/9863 |
| MedLine Reference | 15509789:1276 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v25 i4 p1272 (2005) |
| Journal Link | http://mcb.asm.org/cgi/content/full/25/4/1272 |
| MedLine Reference | 15684380:1026 |
| Organism | Mus musculus |
| CellType | fibroblast |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v274 i31 p21920 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/31/21920 |
| MedLine Reference | 10419513:1213 |
| Organism | Mus musculus |
| CellLineName | NIH 3T3 |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v138 i9 p3695 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/138/9/3695 |
| MedLine Reference | 9275054:1260 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v275 i36 p27815 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/36/27815 |
| MedLine Reference | 10862621:1046 |
| Organism | Mus musculus |
| Tissue | marrow |
|---|---|
| MedLine Reference | 10649448:7 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i17 p15279 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/17/15279 |
| MedLine Reference | 12578843:1030 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 10623469:4 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Tissue | fat |
| Journal | Mol. Cell. Biol |
| Journal Reference | v21 i7 p2521 (2001) |
| Journal Link | http://mcb.asm.org/cgi/content/full/21/7/2521 |
| MedLine Reference | 11259600:1024 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i37 p34322 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/37/34322 |
| MedLine Reference | 12097321:1239 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i4 p2581 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/4/2581 |
| MedLine Reference | 12426306:1029 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| CellLineName | 3T3 |
| Journal | Lipid Res |
| Journal Reference | v44 i2 p271 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/2/271 |
| MedLine Reference | 12576509:1603 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i8 p1441 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/8/1441 |
| MedLine Reference | 12754280:1633 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 11456275:1 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Cell Phys |
| Journal Reference | v286 i2 pC349 (2004) |
| Journal Link | http://ajpcell.physiology.org/cgi/content/full/286/2/C349 |
| MedLine Reference | 14576085:1037 |
| Organism | Mus musculus |
| Journal | Cell Sci |
|---|---|
| Journal Reference | v117 i22 p5393 (2004) |
| Journal Link | http://jcs.biologists.org/cgi/content/full/117/22/5393 |
| MedLine Reference | 15466890:1181 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| CellLineName | 3T3 L1 |
| Journal | Cell Sci |
| Journal Reference | v117 i25 p6217 (2004) |
| Journal Link | http://jcs.biologists.org/cgi/content/full/117/25/6217 |
| MedLine Reference | 15564382:1030 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | EBM |
| Journal Reference | v226 i11 p997 (2001) |
| Journal Link | http://www.ebmonline.org/cgi/content/full/226/11/997 |
| MedLine Reference | 11743135:1074 |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | Endocrin. Metabol |
| Journal Reference | v284 i5 pE1049 (2003) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/284/5/E1049 |
| MedLine Reference | 12554596:1183 |
| CellType | fibroblast |
|---|---|
| CellLineName | NIH 3T3 |
| Journal | J. Biol. Chem |
| Journal Reference | v274 i12 p7946 (1999) |
| Journal Link | http://www.jbc.org/cgi/content/full/274/12/7946 |
| MedLine Reference | 10075691:1037 |
| Organism | Mus musculus |