| Entities | PPARG ---- LEP |
|---|---|
| References | 17 |
| Connectivity | 2 |
| Effect | negative |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5468:inout-urn:agi-llid:3952::negative |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v272 i8 p5283 (1997) |
| Journal Link | http://www.jbc.org/cgi/content/full/272/8/5283 |
| MedLine Reference | 9030601:1219 |
| Sentence | C/EBPalpha but not PPARgamma2 or PPARgamma2/RXR heterodimers bind to the proximal leptin promoter. |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Tissue | fat |
| Journal | Reg.Int.Comp.Phys |
| Journal Reference | v282 i5 pR1429 (2002) |
| Journal Link | http://ajpregu.physiology.org/cgi/content/full/282/5/R1429 |
| MedLine Reference | 11959686:1195 |
| Sentence | PGJ ( 27 ) and other PPAR-gamma ligands ( 4 , 16 ) have been shown to inhibit leptin gene expression in adipocytes, raising the possibility that PGJ is acting via PPAR-gamma in adipose tissue to repress leptin gene expression, independent of its anti-inflammatory effects. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i4 p616 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/4/616 |
| MedLine Reference | 14703507:1031 |
| Sentence | In addition, PPARgamma has been shown to regulate the expression of several secreted cytokines, including leptin and adiponectin, which display systemic effects as signaling molecules ( 3 , 9 ). |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v141 i11 p4021 (2000) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/141/11/4021 |
| MedLine Reference | 11089532:1041 |
| Sentence | Additionally, PPAR-gamma activators up-regulate the expression of acyl-CoA synthetase, fatty acid transporters, and uncoupling protein-2 (UCP2), and down-regulate the expression of leptin and tumor necrosis factor-alpha in adipocytes ( 9 , 10 ). |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Cell |
| Journal Reference | v99 i3 p239 (1999) |
| Journal Link | http://www.cell.com/cgi/content/full/99/3/239 |
| MedLine Reference | 2578575061 |
| Sentence | C/EBPalpha directly and potently transactivates the proximal leptin promoter (He, 1995) while TZD-mediated activation of PPARgamma inhibits leptin gene expression, apparently without binding to leptin gene regulatory sequences (Hollenberg, 1997). |
| CellType | fibroblast |
|---|---|
| Tissue | egg |
| Journal | Cell |
| Journal Reference | v99 i3 p239 (1999) |
| Journal Link | http://www.cell.com/cgi/content/full/99/3/239 |
| MedLine Reference | 2201310474 |
| Sentence | In support of this, the authors show that differentiated embryo fibroblasts heterozygous for PPARgamma, compared to wild-type cells, have increased leptin mRNA levels and increased leptin secretion. |
| CellType | adipocyte |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v53 i6 p1131 (1998) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/53/6/1131 |
| MedLine Reference | 9614218:1121 |
| Sentence | Our data confirm published results for antidiabetic thiazolidinediones (Kallen and Lazar, 1996 ) and show that PPARgamma ligands, but not RORA-activating compounds, inhibit leptin production in differentiated adipocytes. |
| Organism | Rattus norvegicus |
| Tissue | fat |
|---|---|
| Journal | Diabetes |
| Journal Reference | v52 i9 p2249 (2003) |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/52/9/2249 |
| MedLine Reference | 12941763:1033 |
| Sentence | Also, PPARgamma activation is associated with decreased plasma levels of leptin despite increased body adiposity ( 10 , 11 ). |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | Endocrin. Metabol |
| Journal Reference | v280 i6 pE827 (2001) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/280/6/E827 |
| MedLine Reference | 11350765:1340 |
| Sentence | In contrast, thiazoladinedione agonists for PPARgamma transcription factors suppress leptin expression ( 26 ). |
| Tissue | fat |
|---|---|
| Journal | Endocrin. Metabol |
| Journal Reference | v284 i3 pE531 (2003) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/284/3/E531 |
| MedLine Reference | 12556350:1099 |
| Sentence | These data indicated that both PPARalpha and PPARgamma were activated by ragaglitazar, an observation that was also supported by a substantial (60%) reduction in plasma leptin levels in all treated groups (Fig. 1 C ). |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v144 i1 p253 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/1/253 |
| MedLine Reference | 12488352:1189 |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v139 i3 p1013 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/3/1013 |
| MedLine Reference | 9492033:1209 |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i16 p12629 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/16/12629 |
| MedLine Reference | 11278270:1051 |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v276 i36 p33471 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/36/33471 |
| MedLine Reference | 11418615:1222 |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v276 i44 p41245 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/44/41245 |
| MedLine Reference | 11533050:1083 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Organ | paracrine |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i25 p26735 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/25/26735 |
| MedLine Reference | 15067015:1325 |
| Tissue | fat |
|---|---|
| MedLine Reference | 15114521:1 |
| Organism | Rattus norvegicus |