| Entities | PPARG ---- UCP1 |
|---|---|
| References | 18 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:7350:inout-urn:agi-llid:5468::positive |
| Tissue | thyroid |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i19 p16750 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/19/16750 |
| MedLine Reference | 11875072:1020 |
| Sentence | In addition, retinoids ( 6 , 7 ) and synthetic ligands for the peroxisome proliferator-activated receptors PPARalpha ( 8 ) and PPARgamma ( 9 , 10 ) increase rodent UCP1 gene expression. |
| Organism | Rattus norvegicus |
| Tissue | fat |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i35 p33370 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/35/33370 |
| MedLine Reference | 12807871:1013 |
| Sentence | Peroxisome proliferator-activated receptor gamma (PPARgamma) and PPARgamma coactivator 1alpha (PGC-1alpha) activate mouse UCP1 gene transcription. |
| Organism | Rattus norvegicus |
| Organ | liver |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i33 p35017 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/33/35017 |
| MedLine Reference | 15180999:1167 |
| Sentence | In BAT and under fasting conditions, other transcription factors such as PPARdelta, PPARgamma, and thyroid hormone receptor have been shown to control the expression of UCP1 ( 60 ). |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v139 i12 p4920 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/12/4920 |
| MedLine Reference | 9832429:1199 |
| Sentence | Furthermore, we have established that in vivo PPARgamma activation is sufficient to induce UCP-1 protein expression in BAT. |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| CellLineName | HIB-1B |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i2 p1486 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/2/1486 |
| MedLine Reference | 11050084:1035 |
| Sentence | Thus, activation of PPARgamma promotes HIB-1B brown adipocyte differentiation ( 17 ), and up-regulates ucp-1 gene expression ( 18 ). |
| Organism | Rattus norvegicus |
| Tissue | fat |
|---|---|
| Journal | Mol. Cell. Biol |
| Journal Reference | v24 i7 p3057 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/7/3057 |
| MedLine Reference | 15024092:1040 |
| Sentence | The second target of p38 MAPK is the PGC-1alpha protein itself, which then drives transcription of the UCP1 gene through its association with PPARgamma bound to the UCP1 promoter. |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | Diabetes |
| Journal Reference | v52 i9 p2249 (2003) |
| Journal Link | http://diabetes.diabetesjournals.org/cgi/content/full/52/9/2249 |
| MedLine Reference | 12941763:1191 |
| Sentence | In low-fatA?fed rats, both of the PPARgamma activators enhanced brown adipose tissue uncoupling protein-1 expression ( Table 7 ). |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v145 i8 p3925 (2004) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/8/3925 |
| MedLine Reference | 15131020:1009 |
| Sentence | This study was designed to assess whether PPARgamma-induced UCP1 has any functional impact and, if so, whether it involves sympathetic activity. |
| Organism | Mus musculus |
| MedLine Reference | 12044870:1 |
|---|---|
| Sentence | TNF-alpha-induced ERK-dependent peroxisome proliferator activator receptor gamma (PPAR gamma) phosphorylation could be responsible for UCP-1 downregulation. |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v139 i3 p1229 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/3/1229 |
| MedLine Reference | 9492058:1142 |
| Sentence | Furthermore, both families of transcription factors seem also to be involved in thermogenic differentiation, because C/EBPalpha and -beta and PPARgamma have been proposed as transcriptional activators of the UCP1 gene promoter ( 38 , 39 ). |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v271 i47 p29909 (1996) |
| Journal Link | http://www.jbc.org/cgi/content/full/271/47/29909 |
| MedLine Reference | 8939934:1189 |
| CellType | adipocyte |
|---|---|
| CellLineName | HIB-1B |
| MedLine Reference | 8668156:9 |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| MedLine Reference | 10022762:7 |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 10873645:5 |
| Organism | Rattus norvegicus |
| Organ | nervous system |
|---|---|
| MedLine Reference | 10071761:2 |
| Journal | Nutrition |
|---|---|
| Journal Reference | v134 i8 p2154S (2004) |
| Journal Link | http://www.nutrition.org/cgi/content/full/134/8/2154S |
| MedLine Reference | 15284425:1112 |
| CellType | adipocyte |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v144 i2 p581 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/144/2/581 |
| MedLine Reference | 12538620:1309 |
| Organism | Mus musculus |
| Journal | Endocrinology |
|---|---|
| Journal Reference | v139 i6 p2748 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/6/2748 |
| MedLine Reference | 9607781:1110 |
| Organism | Rattus norvegicus |