| Entities | PPARG ---- UCP2 |
|---|---|
| References | 10 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:7351:inout-urn:agi-llid:5468::positive |
| Journal | Endocrin. Metabol |
|---|---|
| Journal Reference | v282 i3 pE522 (2002) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/282/3/E522 |
| MedLine Reference | 11832353:1277 |
| Sentence | PPARgamma modulates UCP2 gene expression indirectly by altering the activity or expression of other transcription factors that bind to the UCP-2 promoter ( 31 ). |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Tissue | muscle |
| Journal | Endocrin. Metabol |
| Journal Reference | v281 i6 pE1197 (2001) |
| Journal Link | http://ajpendo.physiology.org/cgi/content/full/281/6/E1197 |
| MedLine Reference | 11701434:1049 |
| Sentence | Additionally, some groups have shown that PPARgamma agonists are able to increase the expression of UCP-2 mRNA in adipocyte and muscle cells ( 3 , 6 ). |
| Organism | Rattus norvegicus |
| CellLineName | WISTAR |
|---|---|
| Tissue | fat |
| Journal | Endocrinology |
| Journal Reference | v141 i11 p4021 (2000) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/141/11/4021 |
| MedLine Reference | 11089532:1236 |
| Sentence | Similarly, although PPAR-gamma activators increased UCP2 expression in cultured white and brown fat cells ( 30 , 31 ), they had no effect on UCP2 mRNA levels in white adipose tissue in lean or Wistar fatty rats ( 32 , 33 ). |
| Organism | Mus musculus |
| Tissue | islet |
|---|---|
| Organ | pancreas |
| Journal | Endocrinology |
| Journal Reference | v143 i4 p1371 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/143/4/1371 |
| MedLine Reference | 11897694:1207 |
| Sentence | In support of such a notion, the UCP-2 promoter contains a PPAR response element ( 25 ), and the PPAR gamma activator troglitazone has been found to increase UCP2 expression in rat pancreatic islets ( 26 ). |
| Organism | Rattus norvegicus |
| Tissue | islet |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v145 i8 p3563 (2004) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/145/8/3563 |
| MedLine Reference | 15265823:1070 |
| Sentence | Similarly, Patan? et al . ( 25 ) have shown that the expression of PPARgamma is increased in islets exposed to fatty acids, and that a PPARgamma antagonist prevents the increase in UCP2 expression and rescues insulin secretion. |
| CellType | adipocyte |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v139 i12 p4920 (1998) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/139/12/4920 |
| MedLine Reference | 9832429:1205 |
| Sentence | In addition to the effect of TZD treatment on UCP-1, our results demonstrate, for the first time, that in vivo PPARgamma activation is sufficient to increase the expression of both UCP-2 and UCP-3 mRNAs in BAT. |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v276 i14 p10817 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/14/10817 |
| MedLine Reference | 11150307:1025 |
| Sentence | Taken together, these data indicate that PPARgamma activates the UCP2 gene indirectly by altering the activity or expression of other transcription factors that bind to the UCP2 promoter. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i14 p10853 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/14/10853 |
| MedLine Reference | 11278377:1255 |
| Sentence | In contrast, in fully differentiated adipocytes it has been clearly demonstrated that activation of PPARgamma can induce ucp-2 gene expression ( 19 , 20 , 45 ). |
| Tissue | preadipose |
|---|---|
| MedLine Reference | 9299560:6 |
| Sentence | Altogether, the data favor a predominant role of PPARdelta in preadipose cells and the involvement of PPARgamma2 in adipose cells in up-regulating UCP-2 gene expression. |
| Organism | Mus musculus |
| CellLineName | C2C12 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v277 i11 p9562 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/11/9562 |
| MedLine Reference | 11782473:1031 |
| Sentence | Because in C2C12 cells the overexpression of PGC-1, a coactivator of PPARalpha and PPARgamma, up-regulated UCP2 mRNA in the absence of ligands ( 14 ), it was suggested that PPARalpha activation was necessary for UCP2 up-regulation in C2C12 cells. |
| Organism | Rattus norvegicus |