| Entities | PPARG ---- EGR1 |
|---|---|
| References | 3 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5468:inout-urn:agi-llid:1958::positive |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i30 p26808 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/30/26808 |
| MedLine Reference | 12011097:1195 |
| Sentence | Although studies on chromatin remodeling complexes are necessary to further understand the molecular mechanisms of PPARgamma gene expression mediated by Egr-1 , this is beyond the scope of the present study. |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v279 i21 p22057 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/21/22057 |
| MedLine Reference | 15023995:1280 |
| Sentence | Moreover, it was recently reported that Egr-1 positively regulates expression of PPARgamma. |
| CellLineName | VSMC |
|---|---|
| Tissue | smooth muscle |
| MedLine Reference | 12457461:6 |
| Sentence | Furthermore, overexpression of NAB2, a repressor of Egr-1 activation, also blocked the induction of PPAR gamma by TGF beta in VSMC, suggesting that Egr-1 mediates the rapid and transient induction of PPAR gamma by TGF beta. |