| Entities | PPARG ---- replication factor C |
|---|---|
| References | 4 |
| Connectivity | 2 |
| Effect | negative |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5468:inout-urn:agi-complex:3000135::negative |
| CellType | astrocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i12 p11392 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/12/11392 |
| MedLine Reference | 14702344:1055 |
| Sentence | Inhibition of AP-1 binding is due to PPARgamma-mediated interference of JunD binding but not to suppression of JunD expression or JNK activity. |
| Organism | Rattus norvegicus |
| CellType | macrophage |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v276 i36 p34082 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/36/34082 |
| MedLine Reference | 11438523:1021 |
| Sentence | In macrophages, activated PPAR-gamma acts as a transrepressor inhibiting the expression of genes requiring the binding of NF-kappaB, activator protein-1, and signal transducer and activator of transcription-1 to their promoter regions ( 15 , 16 ) . |
| CellLineName | ET |
|---|---|
| Organ | heart |
| MedLine Reference | 12193046:1 |
| Sentence | Peroxisome proliferator-activated receptor gamma (PPAR gamma), a member of the family of nuclear receptors, suppresses activator protein-1 (AP-1). |
| Organism | Rattus norvegicus |
| Tissue | mesangia |
|---|---|
| Journal | Renal Phys |
| Journal Reference | v282 i4 pF639 (2002) |
| Journal Link | http://ajprenal.physiology.org/cgi/content/full/282/4/F639 |
| MedLine Reference | 11880325:1283 |
| Sentence | This speculation is supported by the findings that the activation of PPARgamma decreased AP-1 transcriptional activity and attenuated angiotensin II-mediated upregulation of PAI-1 ( 4 , 28 ). |
| Organism | Mus musculus |