| Entities | PPARG ---- STAT1 |
|---|---|
| References | 3 |
| Connectivity | 2 |
| Effect | unknown |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:6772:inout-urn:agi-llid:5468::unknown |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i46 p47572 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/46/47572 |
| MedLine Reference | 15339920:1021 |
| Sentence | However, acute CT-1 treatment caused an increase in SOCS-3 mRNA in adipocytes and a transient decrease in peroxisome proliferator-activated receptor gamma (PPARgamma) mRNA that was regulated by the binding of STAT1 to the PPARgamma2 promoter. |
| Organism | Mus musculus |
| CellLineName | COS I |
|---|---|
| Journal | Mol. Pharm |
| Journal Reference | v64 i2 p355 (2003) |
| Journal Link | http://molpharm.aspetjournals.org/cgi/content/full/64/2/355 |
| MedLine Reference | 12869640:1114 |
| Sentence | The PPAR inhibitory effect is specific to STAT5b, insofar as troglitazone-activated PPARgamma did not inhibit interferon gamma-activated STAT1 reporter activity ( Fig. 1F ), which is probably mediated by endogenous COS-1 cell STAT1 protein (Zhou and Waxman, 1999b ). |
| CellLineName | 3T3 L1 |
|---|---|
| MedLine Reference | 11554754:7 |
| Sentence | LIF, a potent activator of STAT3 and a weak activator of STAT 1 in these cells, resulted in some binding to the IFNgamma responsive element in the PPARgamma2 promoter that was mediated by STAT 1. |
| Organism | Mus musculus |