| Entities | PPARG ---- IFNG |
|---|---|
| References | 7 |
| Connectivity | 2 |
| Effect | negative |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5468:inout-urn:agi-llid:3458::negative |
| CellType | monocyte |
|---|---|
| Journal | J. Immunol |
| Journal Reference | v172 i12 p7530 (2004) |
| Journal Link | http://www.jimmunol.org/cgi/content/full/172/12/7530 |
| MedLine Reference | 15187132:1226 |
| Sentence | Moreover, studies performed with mutations in PPARgamma that delete the ligand binding domain (pCMX-PPARgamma-DeltaAF2) or alter 2 aa critical for ligand binding suggest that PPARgamma must bind ligand to repress IFN-gamma gene transcription. |
| Organism | Mus musculus |
| Journal | J. Biol. Chem |
|---|---|
| Journal Reference | v277 i6 p4062 (2002) |
| Journal Link | http://www.jbc.org/cgi/content/full/277/6/4062 |
| MedLine Reference | 11733495:1243 |
| Sentence | Phosphorylation of PPARgamma influences the IFNgamma and ligand-dependent degradation of PPARgamma. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| CellLineName | 3T3 L1 |
| Journal | J. Biol. Chem |
| Journal Reference | v276 i10 p7062 (2001) |
| Journal Link | http://www.jbc.org/cgi/content/full/276/10/7062 |
| MedLine Reference | 11106650:1152 |
| Sentence | PPAR gamma turnover is increased in the presence of IFN-gamma. |
| Organism | Mus musculus |
| CellLineName | BV-2 |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i17 p14747 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/17/14747 |
| MedLine Reference | 12584205:1112 |
| Sentence | Furthermore, PPAR-gamma agonists reduced the transcription of not only IFN-gamma-responsive genes but also inflammation-associated genes in BV2 cells (Fig. 4 , b and c ). |
| Organism | Rattus norvegicus |
| CellType | t cell |
|---|---|
| Journal | PNAS |
| Journal Reference | v100 i11 p6712 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/11/6712 |
| MedLine Reference | 12740443:1145 |
| Sentence | The observation that Ro inhibited the expression of the p40 subunit of IL-12 also raised the possibility that PPARgamma might inhibit the production of IFN-gamma itself. |
| Tissue | glia |
|---|---|
| MedLine Reference | 10203248:2 |
| Sentence | PPARgamma activators inhibited iNOS expression by LPS and IFN-gamma. |
| Organism | Rattus norvegicus |
| CellType | macrophage |
|---|---|
| MedLine Reference | 11884448:3 |
| Sentence | Ciglitazone, a PPARgamma ligand, consistently decreased IFN-gamma and IL-2 production by mitogen-activated splenocytes and had modest effects on splenocyte proliferation. |
| Organism | Mus musculus |