| Entities | PPARG ---- NR1H3 |
|---|---|
| References | 4 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5468:inout-urn:agi-llid:10062::positive |
| Tissue | fat |
|---|---|
| Organ | liver |
| MedLine Reference | 15060163:5 |
| Sentence | It is of interest that the PPARgamma gene is a novel target gene of LXR, since the PPARgamma promoter contains the conserved binding site of LXR and was transactivated by the expression of LXRalpha. |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v45 i4 p616 (2004) |
| Journal Link | http://www.jlr.org/cgi/content/full/45/4/616 |
| MedLine Reference | 14703507:1183 |
| Sentence | Thus, LXR activation neither blocks nor augments PPARgamma function in adipose tissue. |
| Organism | Mus musculus |
| Organ | liver |
|---|---|
| Journal | PNAS |
| Journal Reference | v100 i9 p5419 (1996) |
| Journal Link | http://www.pnas.org/cgi/content/full/100/9/5419 |
| MedLine Reference | 12697904:1037 |
| Sentence | We demonstrate that activation of LXR in the liver leads to the induction of glucokinase expression and to the down-regulation of peroxisome proliferator-activated receptor gamma coactivator-1alpha (PGC-1) and genes involved in gluconeogenesis. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i2 p1131 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/2/1131 |
| MedLine Reference | 12414791:1135 |
| Sentence | These results show that although LXRalpha is a direct target gene of PPARgamma, LXR agonists do not merely mimic PPARgamma action in adipocytes, suggesting a unique mechanism for LXR-mediated antidiabetic action. |
| Organism | Mus musculus |