| Entities | PPARG ---- CEBPB |
|---|---|
| References | 24 |
| Connectivity | 2 |
| Effect | positive |
| Owner | Public |
| URN | urn:agi-PromoterBinding:inout-urn:agi-llid:5468:inout-urn:agi-llid:1051::positive |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i21 p21740 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/21/21740 |
| MedLine Reference | 15024020:1045 |
| Sentence | C/EBPbeta and C/EBPdelta then activate the transcription of C/EBPalpha and PPARgamma, which are believed to both be antimitotic and act synergistically to activate the expression of adipocyte-specific genes leading to the differentiated adipocyte phenotype ( 27 , 28 ). |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 15110775:2 |
| Sentence | Circumstantial evidence indicates that C/EBPbeta activates transcription of the C/EBPalpha and PPARgamma genes, both of which possess C/EBP regulatory elements in their proximal promoters. |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| MedLine Reference | 15130516:7 |
| Sentence | As these results in vivo appeared to be contradictory to a transcriptional cascade model in vitro that C/EBPbeta induces the expression of PPARgamma and C/EBPalpha reported, we also examined their expression in the WAT of wild type embryos at different developmental stages. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Cell Phys |
| Journal Reference | v286 i2 pC349 (2004) |
| Journal Link | http://ajpcell.physiology.org/cgi/content/full/286/2/C349 |
| MedLine Reference | 14576085:1037 |
| Sentence | C/EBPbeta and C/EBPdelta activate the synthesis of two critical adipogenic transcription factors, peroxisome proliferator-activated receptor-gamma and C/EBPalpha, which are required for the expression of adipocyte genes. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v140 i7 p2935 (1999) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/140/7/2935 |
| MedLine Reference | 10385383:1038 |
| Sentence | Initially, C/EBPbeta is induced, which induces PPARgamma and subsequently C/EBPalpha ( 1 , 5 , 9 , 10 ). |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 9822687:9 |
| Sentence | The transcriptional induction of PPARgamma, a gene whose expression is induced by C/EBPbeta, and a factor critically involved in terminal differentiation of adipocytes, is impaired in the presence of p38 inhibitors. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 11243868:5 |
| Sentence | ATF-2 regulated gene transcription of PPARgamma, which was synergistically enhanced by p38beta kinase and C/EBPbeta proteins expression. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 11279134:7 |
| Sentence | Taken together, these observations suggest that inhibition of C/EBPbeta activity not only blocks C/EBPalpha and PPARgamma2 expression, but it also renders the preadipocytes dependent on an exogenous PPARgamma ligand for their differentiation into adipocytes. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 10862621:5 |
| Sentence | We further demonstrate that deletion of a region located between amino acids 184-212, upstream of the DNA binding domain, permits C/EBPbeta binding to the PPARgamma2 promoter, implicating an inhibitory region in C/EBPbeta for modulating DNA binding specificity to the PPARgamma2 promoter. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 15158467:4 |
| Sentence | Chromatin immunoprecipitation (ChIP) analysis conducted 24h after induction revealed that C/EBPbeta binds to C/EBP regulatory elements in the proximal promoters of the C/EBPalpha and PPARgamma genes. |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 8754811:3 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 14688407:2 |
| Organism | Mus musculus |
| CellLineName | 3T3 L1 |
|---|---|
| MedLine Reference | 9112250:5 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 9032283:2 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 10623469:4 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Tissue | fat |
| MedLine Reference | 15711576:3 |
| CellType | adipocyte |
|---|---|
| CellLineName | 3T3 |
| Journal | Lipid Res |
| Journal Reference | v44 i2 p271 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/2/271 |
| MedLine Reference | 12576509:1603 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | Lipid Res |
| Journal Reference | v44 i8 p1441 (2003) |
| Journal Link | http://www.jlr.org/cgi/content/full/44/8/1441 |
| MedLine Reference | 12754280:1633 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| MedLine Reference | 11456275:1 |
| Organism | Mus musculus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v278 i17 p15279 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/17/15279 |
| MedLine Reference | 12578843:1030 |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Organ | liver |
| Journal | J. Biol. Chem |
| Journal Reference | v278 i39 p37672 (2003) |
| Journal Link | http://www.jbc.org/cgi/content/full/278/39/37672 |
| MedLine Reference | 12821652:1207 |
| Organism | Rattus norvegicus |
| CellType | adipocyte |
|---|---|
| Journal | J. Biol. Chem |
| Journal Reference | v279 i6 p4471 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/6/4471 |
| MedLine Reference | 14593102:1029 |
| Organism | Mus musculus |
| CellLineName | NIH 3T3 |
|---|---|
| Journal | Endocrinology |
| Journal Reference | v138 i9 p3695 (1997) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/138/9/3695 |
| MedLine Reference | 9275054:1260 |
| Organism | Mus musculus |
| Tissue | fat |
|---|---|
| Journal | Genes & Dev |
| Journal Reference | v18 i16 p1970 (2004) |
| Journal Link | http://www.genesdev.org/cgi/content/full/18/16/1970 |
| MedLine Reference | 15289464:1019 |
| Organism | Mus musculus |