| References | 5 |
|---|---|
| Connectivity | 2 |
| Effect | negative |
| Owner | Public |
| Modification Type | phosphorylation |
| URN | urn:agi-ProtModification:inout-urn:agi-llid:5599:out-urn:agi-llid:5468::negative |
| Entities | PPARG |--- MAPK8 |
| MedLine Reference | 9886850:1004 |
|---|---|
| Sentence | ARTICLES c-Jun N-Terminal Kinase Phosphorylates Peroxisome Proliferator-Activated Receptor-gamma1 and Negatively Regulates Its Transcriptional Activity Heidi S. |
| Organism | Mus musculus |
| Tissue | endocrine |
| Journal | Endocrinology |
| Journal Reference | v140 i1 p392 (1999) |
| Journal Link | http://endo.endojournals.org/cgi/content/full/140/1/392 |
| MedLine Reference | 14656714:1234 |
|---|---|
| Sentence | Later, JNK was also shown to efficiently phosphorylate PPARgamma at the same Ser82 site ( 5 ). |
| Organism | Rattus norvegicus |
| Tissue | fat |
| Journal | Gastr. Liver Phys |
| Journal Reference | v286 i5 pG722 (2004) |
| Journal Link | http://ajpgi.physiology.org/cgi/content/full/286/5/G722 |
| MedLine Reference | 15067015:1032 |
|---|---|
| Sentence | Importantly in adipocytes, both ERK and JNK can phosphorylate PPAR-gamma, which results in repression of its transcriptional activation potential, and adipogenesis ( 33 - 36 ). |
| CellType | adipocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v279 i25 p26735 (2004) |
| Journal Link | http://www.jbc.org/cgi/content/full/279/25/26735 |
| MedLine Reference | 15367687:1139 |
|---|---|
| Sentence | In contrast to ERK5, it has been reported that ERK1/2 and JNK inhibit PPARgamma transcriptional activity through phosphorylation of Ser82 on PPARgamma1 ( 6 ). |
| Journal | Mol. Cell. Biol |
| Journal Reference | v24 i19 p8691 (2004) |
| Journal Link | http://mcb.asm.org/cgi/content/full/24/19/8691 |
| MedLine Reference | 10766862:1255 |
|---|---|
| Sentence | The activation of the c-Jun NH 2 -terminal kinase or the extracellular signal-regulated kinase signaling pathways by extracellular signals (inflammatory cytokines) leads to PPARgamma phosphorylation at serine 82 ( 44 ). |
| Organism | Rattus norvegicus |
| CellType | chondrocyte |
| Journal | J. Biol. Chem |
| Journal Reference | v275 i16 p12243 (2000) |
| Journal Link | http://www.jbc.org/cgi/content/full/275/16/12243 |