| Name | GADD45A |
|---|---|
| Description | growth arrest and DNA-damage-inducible 45 alpha |
| Owner | Public |
| URN | urn:agi-llid:1647 |
| Connectivity | 30 |
| Notes | This gene is a member of a group of genes whose transcript levels are increased following stressful growth arrest conditions and treatment with DNA-damaging agents. The protein encoded by this gene responds to environmental stresses by mediating activation of the p38/JNK pathway via MTK1/MEKK4 kinase. The DNA damage-induced transcription of this gene is mediated by both p53-dependent and -independent mechanisms. |
| Hugo ID | 4095 |
| Microarray ID | 1368947_at |
|---|---|
| l32591mrna_at | |
| l32591mrna_g_at | |
| rc_ai070295_g_at | |
| A_43_P12397 | |
| 102292_at | |
| 1449519_at | |
| l28177_s_at | |
| A_51_P296608 | |
| 203725_at | |
| 1911_s_at | |
| M60974_s_at | |
| A_23_P23221 | |
| A_14_P114342 | |
| A_14_P113109 | |
| A_14_P125604 | |
| M165 | |
| 719 | |
| OH7881 | |
| R232 | |
| OR0391A |
| Chromosome position | 6 C1 |
|---|---|
| 1p31.2-p31.1 | |
| 4q31-q33 |
| GO ID | 0000086 |
|---|---|
| 0003735 | |
| 0005840 | |
| 0006412 | |
| 0000074 | |
| 0005515 | |
| 0006469 | |
| 0006974 | |
| 0007049 | |
| 0007098 | |
| 0000079 | |
| 0005634 | |
| 0006281 | |
| 0006915 | |
| 0007050 |
| Alias | DNA-damage-inducible transcript 1 |
|---|---|
| Growth arrest and DNA-damage-inducible protein | |
| Gadd45alpha | |
| DNA-damage inducible transcript 1 | |
| GA45 | |
| DNA damage-inducible transcript 1 | |
| GA45_HUMAN | |
| DNA-damage-inducible protein gadd45 | |
| GADD45s | |
| DNA- damage inducible transcript I | |
| Gadd45a | |
| DDIT1 | |
| DNA- damage inducible transcript 1 | |
| GADD45 | |
| GADD45 alpha | |
| growth arrest and DNA-damage-inducible, alpha | |
| AA545191 | |
| expressed sequence AA545191 | |
| Growth arrest and DNA-damage-inducible protein GADD45 alpha | |
| growth arrest and DNA-damage-inducible 45 alpha | |
| DDIT I |
| Organism | Human |
|---|---|
| Homo sapiens | |
| Mus musculus | |
| Rattus norvegicus |
| MedLine Reference | 11964479 |
|---|---|
| 12124778 | |
| 15123655 | |
| 10747892 | |
| 10828065 | |
| 7798274 | |
| 7973727 |
| LocusLink ID | 101050 |
|---|---|
| 25112 | |
| 13197 | |
| 1647 |
| FunctionalClass | structural constituent of ribosome |
|---|---|
| protein binding |
| RGD ID | 2654 |
|---|
| Hugo Symbol | GADD45A |
|---|
| Unigene ID | Rn.10250 |
|---|---|
| Mm.1236 | |
| Hs.80409 |
| KEGG pathway | Cell cycle |
|---|---|
| MAPK signaling pathway |
| GO Cellular Component | nucleus |
|---|---|
| ribosome |
| Cell Localization | Nucleus |
|---|
| Pathway | ATM signaling |
|---|---|
| p53 Signaling | |
| FGF2-CD44 | |
| FGF2-FGFR1 | |
| FGF2-FGFR2 | |
| FGF2-FGFR3 | |
| FGF2-GPC1 | |
| FGF2-TGFBR3 | |
| IL6-IL6R | |
| IL6-LIFR | |
| NGFB-NGFR | |
| NGFB-NTRK2 | |
| NGFB-NTRK3 | |
| OSM-CD22 | |
| OSM-IL6ST | |
| OSM-LIFR | |
| PPAR all | |
| PPARgamma | |
| RXR |
| GO Biological Process | negative regulation of protein kinase activity |
|---|---|
| regulation of cell cycle | |
| regulation of cyclin dependent protein kinase activity | |
| DNA repair | |
| apoptosis | |
| cell cycle arrest | |
| regulation of cyclin dependent protein kinase | |
| cell cycle | |
| centrosome cycle | |
| negative regulation of protein kinase | |
| regulation of progression through cell cycle | |
| response to DNA damage stimulus | |
| G2/M transition of mitotic cell cycle | |
| protein biosynthesis |
| MGI ID | 107799 |
|---|
| Swiss-Prot Accession | P24522 |
|---|
| OMIM ID | OMIM:126335 |
|---|---|
| 126335 |
| Source | Curated |
|---|