| Name | INS |
|---|---|
| Description | insulin II |
| Owner | Public |
| URN | urn:agi-llid:3630 |
| Connectivity | 447 |
| Notes | After removal of the precursor signal peptide, proinsulin is post-translationally cleaved into two chains (peptide A and peptide B) that are covalently linked via two disulfide bonds. Binding of this mature form of insulin to the insulin receptor (INSR) stimulates glucose uptake. A variety of mutant alleles with changes in the coding region have been identified. |
| Hugo ID | 6081 |
| Microarray ID | 1370077_at |
|---|---|
| j04807mrna_f_at | |
| rc_ai014020_f_at | |
| 100150_f_at | |
| 1422446_x_at | |
| 98271_f_at | |
| x04724_s_at | |
| A_51_P389597 | |
| A_52_P407060 | |
| J00268 | |
| L15440 | |
| 206598_at | |
| 160038_s_at | |
| j00268_s_at | |
| A_23_P1981 | |
| A_14_P111696 | |
| H124 | |
| OH1697A |
| Chromosome position | 11p15.5 |
|---|---|
| 1q41 | |
| 7 69.1 cM |
| GO ID | 0000187 |
|---|---|
| 0005615 | |
| 0005634 | |
| 0005732 | |
| 0006983 | |
| 0007257 | |
| 0008286 | |
| 0005158 | |
| 0005179 | |
| 0005576 | |
| 0005975 | |
| 0006006 | |
| 0006091 | |
| 0006629 | |
| 0007166 | |
| 0007267 | |
| 0007582 | |
| 0015758 | |
| 0016042 | |
| 0042325 | |
| 0042981 |
| Alias | Mody |
|---|---|
| Ins-2 | |
| Mody4 | |
| AA986540 | |
| expressed sequence AA986540 | |
| Ins2 | |
| Ins2-rs1 | |
| insulin 1 | |
| insulin I | |
| insulin II | |
| INS_HUMAN | |
| insulin 2 | |
| Ins2-rs I | |
| insulin | |
| proinsulin precursor |
| Organism | Human |
|---|---|
| Mus musculus | |
| Rattus norvegicus | |
| Homo sapiens |
| MedLine Reference | 11854325 |
|---|---|
| 12059784 | |
| 12297296 | |
| 12466851 | |
| 12488434 | |
| 12805218 | |
| 381941 |
| LocusLink ID | 16334 |
|---|---|
| 101480 | |
| 24506 | |
| 3630 |
| FunctionalClass | hormone |
|---|---|
| insulin receptor binding |
| RGD ID | 2916 |
|---|
| Hugo Symbol | INS |
|---|
| Unigene ID | Hs.89832 |
|---|---|
| Rn.989 | |
| Mm.4946 |
| KEGG pathway | Dentatorubropallidoluysian atrophy (DRPLA) |
|---|---|
| Regulation of actin cytoskeleton |
| GO Cellular Component | extracellular |
|---|---|
| extracellular space | |
| nucleus | |
| small nucleolar ribonucleoprotein complex | |
| extracellular region |
| Cell Localization | Extracellular |
|---|
| Pathway | Insulin pathway |
|---|---|
| Insulin Receptor Signaling | |
| IGF1R -> MYC signalling pathway | |
| IGF1R -> MYCN signalling pathway | |
| IGF1R -> HIF1A signalling pathway | |
| IGF1R -> TP53 signalling pathway | |
| IGF1R -> ID2 signalling pathway | |
| IGF1R -> RUNX2 signalling pathway | |
| IGF1R -> FOXO1A signalling pathway | |
| IGF1R -> FOS signalling pathway | |
| IGF1R -> SREBF1 signalling pathway | |
| IGF1R -> STAT1 signalling pathway | |
| IGF1R -> STAT3 signalling pathway | |
| IGF1R -> STAT5A signalling pathway | |
| IGF1R -> CEBPA signalling pathway | |
| IGF1R -> CTNNA1 signalling pathway | |
| IGF1R -> EGR1 signalling pathway | |
| IGF2R -> ELF4 signalling pathway | |
| CD2 -> MYC signalling pathway | |
| CD2 -> IRF1 signalling pathway | |
| CD2 -> GATA3 signalling pathway | |
| CD2 -> STAT4 signalling pathway | |
| CD38 -> MYBL1 signalling pathway | |
| CD38 -> TCF3 signalling pathway | |
| INS-EGFR | |
| INS-HLA-DRB1 | |
| INS-IGF1R | |
| INS-TFRC | |
| DuPont 2 | |
| PPAR all | |
| PPARgamma | |
| PPARalpha | |
| HNF4a | |
| NR common targets |
| GO Biological Process | NOT activation of JUNK |
|---|---|
| energy pathways | |
| ER-overload response | |
| NOT activation of JNK | |
| activation of MAPK | |
| glucose transport | |
| insulin receptor signaling pathway | |
| lipid catabolism | |
| regulation of apoptosis | |
| regulation of phosphorylation | |
| activation of JNK | |
| carbohydrate metabolism | |
| cell surface receptor linked signal transduction | |
| cell-cell signaling | |
| generation of precursor metabolites and energy | |
| glucose metabolism | |
| lipid metabolism | |
| physiological process |
| Group | Ligands |
|---|
| MGI ID | 96573 |
|---|
| Swiss-Prot Accession | P01308 |
|---|
| OMIM ID | OMIM:176730 |
|---|---|
| OMIM:125850 | |
| 176730 | |
| 125850 |
| Source | Curated |
|---|